الأربعاء، 18 مارس 2020

Oprah Winfrey

Oprah Winfrey

Orpah Gail Winfrey;[1] January 29, 1954) is an American media executive, actress, talk show host, television producer, and philanthropist. She is best known for her talk show, The Oprah Winfrey Show, broadcast from Chicago, which was the highest-rated television program of its kind in history and ran in national syndication for 25 years from 1986 to 2011.[5] Dubbed the "Queen of All Media",[6] she was the richest African American of the 20th century[7][8] and North America's first black multi-billionaire,[9] and she has been ranked the greatest black philanthropist in American history.[10][11] By 2007, she was sometimes ranked as the most influential woman in the world.[12][13]

Winfrey was born into poverty in rural Mississippi to a teenage single mother and later raised in inner-city Milwaukee. She has stated that she was molested during her childhood and early teens and became pregnant at 14; her son was born prematurely and died in infancy.[14] Winfrey was then sent to live with the man she calls her father, Vernon Winfrey, a barber in Tennessee, and landed a job in radio while still in high school. By 19, she was a co-anchor for the local evening news. Winfrey's often emotional, extemporaneous delivery eventually led to her transfer to the daytime talk show arena, and after boosting a third-rated local Chicago talk show to first place,[15] she launched her own production company and became internationally syndicated.

Credited with creating a more intimate, confessional form of media communication,[16] Winfrey popularized and revolutionized[16][17] the tabloid talk show genre pioneered by Phil Donahue.[16] Through this medium, Winfrey broke 20th-century taboos and allowed LGBT people to enter the mainstream through television appearances.[18][19] In 1994, she was inducted into the National Women's Hall of Fame.[20]

By the mid-1990s, Winfrey had reinvented her show with a focus on literature, self-improvement, mindfulness, and spirituality. Though she was criticized for unleashing a confession culture, promoting controversial self-help ideas,[21] and having an emotion-centered approach,[22] she has also been praised for overcoming adversity to become a benefactor to others.[23] Winfrey had also emerged as a political force in the 2008 presidential race, delivering about one million votes to Barack Obama in the razor close 2008 Democratic primary.[24] In 2013, Winfrey was awarded the Presidential Medal of Freedom by President Obama[25] and honorary doctorate degrees from Duke and Harvard.[26][27] In 2008, she formed her own network, Oprah Winfrey Network (OWN).
Early life
Born Oprah Gail Winfrey, her first name was spelled Orpah (not Oprah) on her birth certificate after the biblical figure in the Book of Ruth, but people mispronounced it regularly and "Oprah" stuck.[1][28] She was born in Kosciusko, Mississippi to an unmarried teenage mother.[29] Her mother, Vernita Lee (1935–2018), was a housemaid.[30][31] Winfrey's biological father is usually noted as Vernon Winfrey (born c. 1933), a coal miner turned barber turned city councilman who had been in the Armed Forces when she was born.[30] However, Mississippi farmer and World War II Veteran Noah Robinson Sr. (born c. 1925) has claimed to be her biological father.[32][33][34]

A genetic test in 2006 determined that her matrilineal line originated among the Kpelle ethnic group, in the area that today is Liberia. Her genetic makeup was determined to be 89% Sub-Saharan African, 8% Native American, and 3% East Asian. However, given the imprecision of genetic testing, the East Asian markers may actually be Native American.[35]

After Winfrey's birth, her mother traveled north, and Winfrey spent her first six years living in rural poverty with her maternal grandmother, Hattie Mae (Presley) Lee (April 15, 1900 – February 27, 1963). Her grandmother was so poor that Winfrey often wore dresses made of potato sacks, for which other children made fun of her.[29][36] Her grandmother taught her to read before the age of three and took her to the local church, where she was nicknamed "The Preacher" for her ability to recite Bible verses. When Winfrey was a child, her grandmother was reportedly abusive.[37]

At age six, Winfrey moved to an inner-city neighborhood in Milwaukee, Wisconsin, with her mother, who was less supportive and encouraging than her grandmother had been, largely as a result of the long hours she worked as a maid.[38] Around this time, Lee had given birth to another daughter, Winfrey's younger half-sister, Patricia[39] who died of causes related to cocaine addiction in February 2003 at age 43.[40]

By 1962, Lee was having difficulty raising both daughters, so Winfrey was temporarily sent to live with Vernon in Nashville, Tennessee.[41] While Winfrey was in Nashville, Lee gave birth to a third daughter[42] who was put up for adoption in the hopes of easing the financial straits that had led to Lee's being on welfare, and was later also named Patricia.[43] Winfrey did not learn she had a second half-sister until 2010.[43] By the time Winfrey moved back with her mother, Lee had also given birth to Winfrey's half-brother Jeffrey, who died of AIDS-related causes in 1989.[40]

Winfrey has stated she was molested by her cousin, uncle, and a family friend, starting when she was nine years old, something she first announced on a 1986 episode of her TV show regarding sexual abuse.[44][45] When Winfrey discussed the alleged abuse with family members at age 24, they reportedly refused to believe her account.[46]

Winfrey once commented that she had chosen not to be a mother because she had not been mothered well.[47] At 13, after suffering what she described as years of abuse, Winfrey ran away from home.[28] When she was 14, she became pregnant but her son was born prematurely and he died shortly after birth.[48] Winfrey later stated she felt betrayed by the family member who had sold the story of her son to the National Enquirer in 1990.[49]

She attended Lincoln High School in Milwaukee, but after early success in the Upward Bound program, was transferred to the affluent suburban Nicolet High School. Upon transferring, she said she was continually reminded of her poverty as she rode the bus to school with fellow African-Americans, some of whom were servants of her classmates' families. She began to rebel and steal money from her mother in an effort to keep up with her free-spending peers.[50][51]

As a result, her mother once again sent her to live with Vernon in Nashville, although this time she did not take her back. Vernon was strict but encouraging, and made her education a priority. Winfrey became an honors student, was voted Most Popular Girl, and joined her high school speech team at East Nashville High School, placing second in the nation in dramatic interpretation.[52][53]

She won an oratory contest, which secured her a full scholarship to Tennessee State University, a historically black institution, where she studied communication. Her first job as a teenager was working at a local grocery store.[54] At the age of 17, Winfrey won the Miss Black Tennessee beauty pageant.[55][56] She also attracted the attention of the local black radio station, WVOL, which hired her to do the news part-time.[44] She worked there during her senior year of high school, and again while in her first two years of college.

Winfrey's career choice in media would not have surprised her grandmother, who once said that ever since Winfrey could talk, she was on stage. As a child, she played games interviewing her corncob doll and the crows on the fence of her family's property. Winfrey later acknowledged her grandmother's influence, saying it was Hattie Mae who had encouraged her to speak in public and "gave me a positive sense of myself".[57]

Television
Working in local media, she was both the youngest news anchor and the first black female news anchor at Nashville's WLAC-TV. She moved to Baltimore's WJZ-TV in 1976 to co-anchor the six o'clock news. In 1977, she was removed as co-anchor and worked in lower profile positions at the station. She was then recruited to join Richard Sher as co-host of WJZ's local talk show People Are Talking, which premiered on August 14, 1978. She also hosted the local version of Dialing for Dollars.[58]

In 1983, Winfrey relocated to Chicago to host WLS-TV's low-rated half-hour morning talk show, AM Chicago. The first episode aired on January 2, 1984. Within months after Winfrey took over, the show went from last place in the ratings to overtaking Donahue as the highest-rated talk show in Chicago. The movie critic Roger Ebert persuaded her to sign a syndication deal with King World. Ebert predicted that she would generate 40 times as much revenue as his television show, At the Movies.[59] It was renamed The Oprah Winfrey Show, expanded to a full hour and broadcast nationally beginning September 8, 1986.[60] Winfrey's syndicated show brought in double Donahue's national audience, displacing Donahue as the number-one daytime talk show in America. Their much-publicized contest was the subject of enormous scrutiny. TIME magazine wrote:

Few people would have bet on Oprah Winfrey's swift rise to host of the most popular talk show on TV. In a field dominated by white males, she is a black female of ample bulk. As interviewers go, she is no match for, say, Phil Donahue ... What she lacks in journalistic toughness, she makes up for in plainspoken curiosity, robust humor and, above all empathy. Guests with sad stories to tell are apt to rouse a tear in Oprah's eye ... They, in turn, often find themselves revealing things they would not imagine telling anyone, much less a national TV audience. It is the talk show as a group therapy session.[61]
TV columnist Howard Rosenberg said, "She's a roundhouse, a full course meal, big, brassy, loud, aggressive, hyper, laughable, lovable, soulful, tender, low-down, earthy, and hungry. And she may know the way to Phil Donahue's jugular."[62] Newsday's Les Payne observed, "Oprah Winfrey is sharper than Donahue, wittier, more genuine, and far better attuned to her audience, if not the world"[62] and Martha Bayles of The Wall Street Journal wrote, "It's a relief to see a gab-monger with a fond but realistic assessment of her own cultural and religious roots."[62]

In the early years of The Oprah Winfrey Show, the program was classified as a tabloid talk show. In the mid-1990s, Winfrey adopted a less tabloid-oriented format, hosting shows on broader topics such as heart disease, geopolitics, spirituality, and meditation, interviewing celebrities on social issues they were directly involved with, such as cancer, charity work, or substance abuse, and hosting televised giveaways including shows where every audience member received a new car (donated by General Motors) or a trip to Australia (donated by Australian tourism bodies).[63][64] Later years of the show faced analysis that Winfrey was promoting junk science.[65]

In addition to her talk show, Winfrey also produced and co-starred in the 1989 drama miniseries The Women of Brewster Place and a short-lived spin-off, Brewster Place. As well as hosting and appearing on television shows, Winfrey co-founded the women's cable television network Oxygen which was the initial network for her Oprah After the Show program from 2002 to 2006 before moving to Oprah.com when Winfrey sold her stake in the network. She is also the president of Harpo Productions (Oprah spelled backwards). She also moderated three ABC Afterschool Specials from 1992 to 1994.

On January 15, 2008, Winfrey and Discovery Communications announced plans to change Discovery Health Channel into a new channel called OWN: Oprah Winfrey Network. It was scheduled to launch in 2009 but was delayed, and actually launched on January 1, 2011.[66]

The series finale of The Oprah Winfrey Show aired on May 25, 2011.[67]

In January 2017, CBS announced that Winfrey would join 60 Minutes as a special contributor on the Sunday evening news magazine program starting in September 2017.[68] The National Museum of African American History and Culture in 2018 opened a special exhibit on Winfrey's cultural influence through television.[69] Winfrey left 60 Minutes by the end of 2018.[70]

In June 2018, Apple announced a multi-year content partnership with Winfrey, in which it was agreed that Winfrey would create new original programs exclusively for Apple's streaming service, Apple TV+.[71]

Celebrity interviews
In 1993, Winfrey hosted a rare prime-time interview with Michael Jackson, which became the fourth most-watched event in American television history as well as the most watched interview ever, with an audience of 36.5 million.[72] On December 1, 2005, Winfrey appeared on the Late Show with David Letterman to promote the new Broadway musical The Color Purple,[73] of which she was a producer, joining the host for the first time in 16 years. The episode was hailed by some as the "television event of the decade" and helped Letterman attract his largest audience in more than 11 years: 13.45 million viewers.[74] Although a much-rumored feud was said to have been the cause of the rift,[73] both Winfrey and Letterman balked at such talk. "I want you to know, it's really over, whatever you thought was happening", said Winfrey. On September 10, 2007, Letterman made his first appearance on The Oprah Winfrey Show, as its season premiere was filmed in New York City.[75]

In 2006, rappers Ludacris, 50 Cent, and Ice Cube criticized Winfrey for what they perceived as an anti-hip hop bias. In an interview with GQ magazine, Ludacris said that Winfrey gave him a "hard time" about his lyrics, and edited comments he made during an appearance on her show with the cast of the film Crash. He also said that he wasn't initially invited on the show with the rest of the cast.[76] Winfrey responded by saying that she is opposed to rap lyrics that "marginalize women", but enjoys some artists, including Kanye West, who appeared on her show. She said she spoke with Ludacris backstage after his appearance to explain her position and said she understood that his music was for entertainment purposes, but that some of his listeners might take it literally. In September 2008, Winfrey received criticism after Matt Drudge of the Drudge Report[77] reported that Winfrey refused to have Sarah Palin on her show, allegedly because of Winfrey's support for Barack Obama.[78] Winfrey denied the report, maintaining that there never was a discussion regarding Palin's appearing on her show. She said that after she made public her support for Obama, she decided that she would not let her show be used as a platform for any of the candidates.[78] Although Obama appeared twice on her show, those appearances were prior to his declaring himself a candidate. Winfrey added that Palin would make a fantastic guest and that she would love to have her on the show after the election, which she did on November 18, 2009.[78]

In 2009, Winfrey was criticized for allowing actress Suzanne Somers to appear on her show to discuss hormone treatments that are not accepted by mainstream medicine.[79] Critics have also suggested that Winfrey is not tough enough when questioning celebrity guests or politicians whom she appears to like.[80] Lisa de Moraes, a media columnist for The Washington Post, stated: "Oprah doesn't do follow-up questions unless you're an author who's embarrassed her by fabricating portions of a supposed memoir she's plugged for her book club."[81]

Other media
Film
In 1985, Winfrey co-starred in Steven Spielberg's The Color Purple as distraught housewife Sofia. She was nominated for an Academy Award for Best Supporting Actress for her performance. The Alice Walker novel went on to become a Broadway musical which opened in late 2005, with Winfrey credited as a producer. In October 1998, Winfrey produced and starred in the film Beloved, based on Toni Morrison's Pulitzer Prize-winning novel of the same name. To prepare for her role as Sethe, the protagonist and former slave, Winfrey experienced a 24-hour simulation of the experience of slavery, which included being tied up and blindfolded and left alone in the woods. Despite major advertising, including two episodes of her talk show dedicated solely to the film, and moderate to good critical reviews, Beloved opened to poor box-office results, losing approximately $30 million. While promoting the movie, co-star Thandie Newton described Winfrey as "a very strong technical actress and it's because she's so smart. She's acute. She's got a mind like a razor blade."[82] In 2005, Harpo Productions released a film adaptation of Zora Neale Hurston's 1937 novel Their Eyes Were Watching God. The made-for-television film was based upon a teleplay by Suzan-Lori Parks and starred Halle Berry in the lead female role.

In late 2008, Winfrey's company Harpo Films signed an exclusive output pact to develop and produce scripted series, documentaries, and movies for HBO.[83]

Oprah voiced Gussie the goose in Charlotte's Web (2006) and voiced Judge Bumbleton in Bee Movie (2007), co-starring the voices of Jerry Seinfeld and Renée Zellweger. In 2009, Winfrey provided the voice for the character of Eudora, the mother of Princess Tiana, in Disney's The Princess and the Frog and in 2010, narrated the US version of the BBC nature program Life for Discovery.

In 2018, Winfrey starred as Mrs. Which in the film adaptation of Madeleine L'Engle's novel A Wrinkle in Time.[84] She also lent her voice to an animated virtual-reality short film written and directed by Eric Darnell, starring John Legend, titled Crow: The Legend, telling a native American origin tale.[85]

Publishing and writing
Winfrey has co-authored five books. At the announcement of a weight-loss book in 2005, co-authored with her personal trainer Bob Greene, it was said that her undisclosed advance fee had broken the record for the world's highest book advance fee, previously held by the autobiography of former U.S. President Bill Clinton.[86]

In 2015, her memoir, The Life You Want, was announced following on her tour of the same name,[87][88] and scheduled for publication in 2017,[89] but was "indefinitely postponed" in 2016.[90]

Winfrey publishes the magazine: O, The Oprah Magazine and from 2004 to 2008 also published a magazine called O At Home.[91] In 2002, Fortune called O, the Oprah Magazine the most successful start-up ever in the industry.[92] Although its circulation had declined by more than 10 percent (to 2.4 million) from 2005 to 2008,[93] the January 2009 issue was the best selling issue since 2006.[94] The audience for her magazine is considerably more upscale than for her TV show; the average reader earns well above the median for U.S. women.[92]

Online
Winfrey's company created the Oprah.com website to provide resources and interactive content relating to her shows, magazines, book club, and public charity. Oprah.com averages more than 70 million page views and more than six million users per month, and receives approximately 20,000 e-mails each week.[95] Winfrey initiated "Oprah's Child Predator Watch List", through her show and website, to help track down accused child molesters. Within the first 48 hours, two of the featured men were captured.[96]

Radio
On February 9, 2006, it was announced that Winfrey had signed a three-year, $55-million contract with XM Satellite Radio to establish a new radio channel. The channel, Oprah Radio, features popular contributors to The Oprah Winfrey Show and O, The Oprah Magazine including Nate Berkus, Dr. Mehmet Oz, Bob Greene, Dr. Robin Smith, and Marianne Williamson. Oprah & Friends began broadcasting at 11:00 am ET, September 25, 2006, from a new studio at Winfrey's Chicago headquarters. The channel broadcasts 24 hours a day, seven days a week on XM Radio Channel 156. Winfrey's contract requires her to be on the air 30 minutes a week, 39 weeks a year.[97]

Food business
In 2015, Winfrey purchased a minority stake in the publicly traded company Weight Watchers for a reported $34 million. By 2020, the value of those shares had increased to as much as $430 million.[98] She also is an investor in True Food Kitchen, a restaurant chain founded by author Andrew Weil.

Personal life
Homes
Winfrey currently lives on "The Promised Land", her 42-acre (17-ha) estate with ocean and mountain views in Montecito, California. Winfrey also owns a house in Lavallette, New Jersey; an apartment in Chicago; an estate on Fisher Island, Florida; a ski house in Telluride, Colorado; and properties on Maui, Hawaii, Antigua and Orcas Island in Washington State.

Romantic history
Winfrey's high school sweetheart Anthony Otey recalled an innocent courtship that began in Winfrey's senior year of high school, from which he saved hundreds of love notes; Winfrey conducted herself with dignity and as a model student.[99] The two spoke of getting married, but Otey claimed to have always secretly known that Winfrey was destined for a far greater life than he could ever provide.[100] She broke up with him on Valentine's Day of her senior year.[100][101]

In 1971, several months after breaking up with Otey, Winfrey met William "Bubba" Taylor at Tennessee State University. According to CBS journalist George Mair, Taylor was Winfrey's "first intense, to die for love affair". Winfrey helped get Taylor a job at WVOL, and according to Mair, "did everything to keep him, including literally begging him on her knees to stay with her."[102] Taylor, however, was unwilling to leave Nashville with Winfrey when she moved to Baltimore to work at WJZ-TV in June 1976. "We really did care for each other", Winfrey would later recall. "We shared a deep love. A love I will never forget."[103]

In the 1970s, Winfrey had a romantic relationship with John Tesh. Biographer Kitty Kelley claims that Tesh split with Winfrey over the pressure of having an interracial relationship.[104]

When WJZ-TV management criticized Winfrey for crying on the air while reporting tragedies and were unhappy with her physical appearance (especially when her hair fell out as the result of a bad perm), Winfrey turned to reporter Lloyd Kramer for comfort. "Lloyd was just the best", Winfrey would later recall. "That man loved me even when I was bald! He was wonderful. He stuck with me through the whole demoralizing experience. That man was the most fun romance I ever had."[105]

According to Mair, when Kramer moved to NBC in New York, Winfrey had a love affair with a married man who had no intention of leaving his wife.[106] Winfrey would later recall: "I'd had a relationship with a man for four years. I wasn't living with him. I'd never lived with anyone—and I thought I was worthless without him. The more he rejected me, the more I wanted him. I felt depleted, powerless. At the end, I was down on the floor on my knees groveling and pleading with him".[107] Winfrey became so depressed that on September 8, 1981, she wrote a suicide note to best friend Gayle King instructing King to water her plants.[107] "That suicide note had been much overplayed" Winfrey told Ms. magazine. "I couldn't kill myself. I would be afraid the minute I did it, something really good would happen and I'd miss it."[108]

According to Winfrey, her emotional turmoil gradually led to a weight problem: "The reason I gained so much weight in the first place and the reason I had such a sorry history of abusive relationships with men was I just needed approval so much. I needed everyone to like me, because I didn't like myself much. So I'd end up with these cruel self-absorbed guys who'd tell me how selfish I was, and I'd say 'Oh thank you, you're so right' and be grateful to them. Because I had no sense that I deserved anything else. Which is also why I gained so much weight later on. It was the perfect way of cushioning myself against the world's disapproval."[108]

Winfrey later confessed to smoking crack cocaine with a man she was romantically involved with during the same era. She explained on her show: "I always felt that the drug itself is not the problem but that I was addicted to the man." She added: "I can't think of anything I wouldn't have done for that man."[109]

Winfrey was allegedly involved in a second drug-related love affair. Self-proclaimed former boyfriend Randolph Cook said they lived together for several months in 1985 and did drugs. In 1997, Cook tried to sue Winfrey for $20 million for allegedly blocking a tell-all book about their alleged relationship.[110][111]

Also, in the mid-1980s, Winfrey briefly dated movie critic Roger Ebert, whom she credits with advising her to take her show into syndication.[59]

In 1985, before Winfrey's Chicago talk show had gone national, Haitian filmmaker Reginald Chevalier claims he appeared as a guest on a look-alike segment and began a relationship with Winfrey involving romantic evenings at home, candlelit baths, and dinners with Michael Jordan and Danny Glover. Chevalier says Winfrey ended the relationship when she met Stedman Graham.[112]

Winfrey and her boyfriend Stedman Graham have been together since 1986. They were engaged to be married in November 1992, but the ceremony never took place.[113]

Close friends
Winfrey's best friend since their early twenties is Gayle King. King was formerly the host of The Gayle King Show and is currently an editor of O, the Oprah Magazine. Since 1997, when Winfrey played the therapist on an episode of the sitcom Ellen in which Ellen DeGeneres came out of the closet, Winfrey and King have been the target of persistent rumors that they were gay. "I understand why people think we're gay", Winfrey says in the August 2006 issue of O magazine. "There isn't a definition in our culture for this kind of bond between women. So I get why people have to label it—how can you be this close without it being sexual?"[114] "I've told nearly everything there is to tell. All my stuff is out there. People think I'd be so ashamed of being gay that I wouldn't admit it? Oh, please."[114]

Winfrey has also had a long friendship with Maria Shriver, after they met in Baltimore.[115][116] Winfrey considered Maya Angelou, author of I Know Why the Caged Bird Sings, her mentor and close friend; she called Angelou her "mother-sister-friend."[117] Winfrey hosted a week-long Caribbean cruise for Angelou and 150 guests for Angelou's 70th birthday in 1998, and in 2008, threw her "an extravagant 80th birthday celebration" at Donald Trump's Mar-a-Lago club in Palm Beach, Florida.[118]

Time reported that a potential Oprah presidency and status as a #MeToo champion could be hampered by the cozy relationship she had with Harvey Weinstein.[119]

Personal wealth
Born in rural poverty, and raised by a mother dependent on government welfare payments in a poor urban neighborhood, Winfrey became a millionaire at the age of 32 when her talk show received national syndication. Winfrey negotiated ownership rights to the television program and started her own production company. At the age of 41, Winfrey had a net worth of $340 million and replaced Bill Cosby as the only African American on the Forbes 400.[120] By 2000, with a net worth of $800 million, Winfrey is believed to have been the richest African American of the 20th century. There has been a course taught at the University of Illinois focusing on Winfrey's business acumen, namely: "History 298: Oprah Winfrey, the Tycoon".[121] Winfrey was the highest paid television entertainer in the United States in 2006, earning an estimated $260 million during the year, five times the sum earned by second-place music executive Simon Cowell.[122] By 2008, her yearly income had increased to $275 million.[123]

Forbes' list of The World's Billionaires has listed Winfrey as the world's only black billionaire from 2004 to 2006 and as the first black woman billionaire in the world that was achieved in 2003.[120] As of 2014, Winfrey had a net worth in excess of 2.9 billion dollars[124] and had overtaken former eBay CEO Meg Whitman as the richest self-made woman in America.[125]

Religious views
Oprah was raised a Baptist. In her early life, she would speak at local, mostly African American congregations of the Southern Baptist Convention that were often deeply religious and familiar with such themes as evangelical Protestantism, the Black church, and being born-again.[126][127][128]

She was quoted as saying: "I have church with myself: I have church walking down the street. I believe in the God force that lives inside all of us, and once you tap into that, you can do anything."[129] She also stated, "Doubt means don't. When you don't know what to do, do nothing until you do know what to do. Because the doubt is your inner voice or the voice of God or whatever you choose to call it. It is your instinct trying to tell you something is off. That's how I have found myself to be led spiritually, because that's your spiritual voice saying to you, 'let's think about it.' So when you don't know what to do, do nothing."[130]

Oprah has stated that she is a Christian and her favorite Bible verse is Acts 17:28.[131]

Influence
Rankings
Winfrey was called "arguably the world's most powerful woman" by CNN and Time.com,[132] "arguably the most influential woman in the world" by The American Spectator,[133] "one of the 100 people who most influenced the 20th Century" and "one of the most influential people" from 2004 to 2011 by TIME. Winfrey is the only person in the world to have appeared in the latter list on ten occasions.[134]

At the end of the 20th century, Life listed Winfrey as both the most influential woman and the most influential black person of her generation, and in a cover story profile the magazine called her "America's most powerful woman".[135] In 2007, USA Today ranked Winfrey as the most influential woman and most influential black person of the previous quarter-century.[136] Ladies Home Journal also ranked Winfrey number one in their list of the most powerful women in America and Senator Barack Obama has said she "may be the most influential woman in the country".[137] In 1998, Winfrey became the first woman and first African American to top Entertainment Weekly's list of the 101 most powerful people in the entertainment industry.[138] Forbes named her the world's most powerful celebrity in 2005,[139] 2007,[140] 2008,[123] 2010,[141] and 2013.[142]

As chairman of Harpo Inc., she was named the most powerful woman in entertainment by The Hollywood Reporter in 2008.[143] She has been listed as one of the most powerful 100 women in the world by Forbes, ranking 14th in 2014.[144] In 2010, Life magazine named Winfrey one of the 100 people who changed the world, alongside such luminaries as Jesus Christ, Elvis Presley, and Lady Mary Wortley Montagu. Winfrey was the only living woman to make the list.[145]

Columnist Maureen Dowd seems to agree with such assessments: "She is the top alpha female in this country. She has more credibility than the president. Other successful women, such as Hillary Clinton and Martha Stewart, had to be publicly slapped down before they could move forward. Even Condi has had to play the protegé with Bush. None of this happened to Oprah – she is a straight ahead success story.[146] Vanity Fair wrote: "Oprah Winfrey arguably has more influence on the culture than any university president, politician, or religious leader, except perhaps the Pope.[147] Bill O'Reilly said: "this is a woman that came from nothing to rise up to be the most powerful woman, I think, in the world. I think Oprah Winfrey is the most powerful woman in the world, not just in America. That's – anybody who goes on her program immediately benefits through the roof. I mean, she has a loyal following; she has credibility; she has talent; and she's done it on her own to become fabulously wealthy and fabulously powerful."[148]

In 2005, Winfrey was named the greatest woman in American history as part of a public poll as part of The Greatest American. She was ranked No. 9 overall on the list of greatest Americans. However, polls estimating Winfrey's personal popularity have been inconsistent. A November 2003 Gallup poll estimated that 73% of American adults had a favorable view of Winfrey. Another Gallup poll in January 2007 estimated the figure at 74%, although it dropped to 66% when Gallup conducted the same poll in October 2007. A December 2007 Fox News poll put the figure at 55%.[149] According to Gallup's annual most admired poll, Americans consistently rank Winfrey as one of the most admired women in the world. Her highest rating came in 2007[150] when she was statistically tied with Hillary Clinton for first place.[151] In a list compiled by the British magazine New Statesman in September 2010, she was voted 38th in the list of "The World's 50 Most Influential Figures 2010".[152]

In 1989, she was accepted into the NAACP Image Award Hall of Fame.[153]

"Oprahfication"
The Wall Street Journal coined the term "Oprahfication", meaning public confession as a form of therapy.[154] By confessing intimate details about her weight problems, tumultuous love life, and sexual abuse, and crying alongside her guests, Winfrey has been credited by Time magazine with creating a new form of media communication known as "rapport talk" as distinguished from the "report talk" of Phil Donahue: "Winfrey saw television's power to blend public and private; while it links strangers and conveys information over public airwaves, TV is most often viewed in the privacy of our homes. Like a family member, it sits down to meals with us and talks to us in the lonely afternoons. Grasping this paradox, ... She makes people care because she cares. That is Winfrey's genius, and will be her legacy, as the changes she has wrought in the talk show continue to permeate our culture and shape our lives."[155]

Observers have also noted the "Oprahfication" of politics such as "Oprah-style debates" and Bill Clinton being described as "the man who brought Oprah-style psychobabble and misty confessions to politics."[156] Newsweek stated: "Every time a politician lets his lip quiver or a cable anchor 'emotes' on TV, they nod to the cult of confession that Oprah helped create.[157]

The November 1988 Ms. observed that "in a society where fat is taboo, she made it in a medium that worships thin and celebrates a bland, white-bread prettiness of body and personality [...] But Winfrey made fat sexy, elegant – damned near gorgeous – with her drop-dead wardrobe, easy body language, and cheerful sensuality."[158]

Mainstream acceptance of LGBT people
While Phil Donahue has been credited with pioneering the tabloid talk show genre, Winfrey's warmth, intimacy, and personal confession popularized and changed it.[16][17] Her success at popularizing the tabloid talk show genre opened up a thriving industry that has included Ricki Lake, The Jenny Jones Show, and The Jerry Springer Show. Sociologists such as Vicki Abt criticized tabloid talk shows for redefining social norms. In her book Coming After Oprah: Cultural Fallout in the Age of the TV talk show, Abt warned that the media revolution that followed Winfrey's success was blurring the lines between "normal" and "deviant" behavior. In the book Freaks Talk Back,[18] Yale sociology professor Joshua Gamson credits the tabloid talk show genre with providing much needed high impact media visibility for gay, bisexual, transsexual, and transgender (LGBT) people and doing more to make them mainstream and socially acceptable than any other development of the 20th century. In the book's editorial review, Michael Bronski wrote, "In the recent past, lesbians, gay men, bisexuals, and transgendered people had almost no presence on television. With the invention and propagation of tabloid talk shows such as Jerry Springer, Jenny Jones, Oprah, and Geraldo, people outside the sexual mainstream now appear in living rooms across America almost every day of the week."[159] Gamson credits the tabloid talk show with making alternative sexual orientations and identities more acceptable in mainstream society. Examples include a Time magazine article[page needed] on early 21st-century gays coming out of the closet at an increasingly younger age and on plummeting gay suicide rates. Gamson also believes that tabloid talk shows caused gays to be accepted on more traditional forms of media.

In April 1997, Winfrey played the therapist in "The Puppy Episode" on the sitcom Ellen to whom the character (and the real-life Ellen DeGeneres) said she was a lesbian.

"The Oprah Effect"
The power of Winfrey's opinions and endorsement to influence public opinion, especially consumer purchasing choices, has been dubbed "the Oprah Effect".[160] The effect has been documented or alleged in domains as diverse as book sales, beef markets, and election voting. Late in 1996,[161] Winfrey introduced the Oprah's Book Club segment to her television show. The segment focused on new books and classics and often brought obscure novels to popular attention. The book club became such a powerful force that whenever Winfrey introduced a new book as her book-club selection, it instantly became a best-seller; for example, when she selected the classic John Steinbeck novel East of Eden, it soared to the top of the book charts. Being recognized by Winfrey often means a million additional book sales for an author.[162] In Reading with Oprah: The Book Club that Changed America (2005), Kathleen Rooney describes Winfrey as "a serious American intellectual who pioneered the use of electronic media, specifically television and the Internet, to take reading – a decidedly non-technological and highly individual act – and highlight its social elements and uses in such a way to motivate millions of erstwhile non-readers to pick up books."

When author Jonathan Franzen's book was selected for the Book Club, he reportedly "cringed" and said selected books tend to be "schmaltzy".[163] After James Frey's A Million Little Pieces was found to contain fabrications in 2006, Winfrey confronted him on her show over the breach of trust. In 2009, Winfrey apologized to Frey for the public confrontation.[164] During a show about mad cow disease with Howard Lyman (aired on April 16, 1996), Winfrey said she was stopped cold from eating another burger. Texas cattlemen sued her and Lyman in early 1998 for "false defamation of perishable food" and "business disparagement", claiming that Winfrey's remarks sent cattle prices tumbling, costing beef producers $11 million. Winfrey was represented by attorney Chip Babcock and, on February 26, after a two-month trial in an Amarillo, Texas, court, a jury found Winfrey and Lyman were not liable for damages.[165][166] During the lawsuit, Winfrey hired Phil McGraw's company Courtroom Sciences, Inc. to help her analyze and read the jury.[167] Winfrey's ability to launch other successful talk shows such as Dr. Phil, Dr. Oz, and Rachael Ray has also been cited as examples of "The Oprah Effect".[168]

Politics
Matthew Baum and Angela Jamison performed an experiment testing their hypothesis, “Politically unaware individuals who consume soft news will be more likely to vote consistently than their counterparts who do not consume soft news”.[169] In their studies, they found that low-awareness individuals who watch soft news shows, such as The Oprah Winfrey Show are 14% more likely to vote consistently than low-awareness individuals who only watch hard news
Winfrey endorsed presidential candidate Barack Obama in the 2008 presidential election,[170][171][172] the first time she endorsed a political candidate running for office.[173] Winfrey held a fundraiser for Obama on September 8, 2007, at her Santa Barbara estate. In December 2007, Winfrey joined Obama for a series of rallies in the early primary states of Iowa, New Hampshire, and South Carolina. The Columbia, South Carolina, event on December 9, 2007, drew a crowd of nearly 30,000, the largest for any political event of 2007.[174] An analysis by two economists at the University of Maryland, College Park estimated that Winfrey's endorsement was responsible for between 420,000 and 1,600,000 votes for Obama in the Democratic primary alone, based on a sample of states that did not include Texas, Michigan, North Dakota, Kansas, or Alaska. The results suggest that in the sampled states, Winfrey's endorsement was responsible for the difference in the popular vote between Barack Obama and Hillary Clinton.[175] The governor of Illinois, Rod Blagojevich, reported being so impressed by Winfrey's endorsement that he considered offering Winfrey Obama's vacant senate seat, describing Winfrey as "the most instrumental person in electing Barack Obama president", with "a voice larger than all 100 senators combined".[176] Winfrey responded by stating that although she was absolutely not interested, she did feel she could be a senator.[177]

In April 2014, Winfrey spoke for more than 20 minutes at a fundraiser in Arlington, Virginia, for Lavern Chatman, a candidate in a primary to nominate a Democratic Party candidate for election to the U.S. House of Representatives. Winfrey participated in the event even after reports had revealed that Chatman had been found liable in 2001 for her role in a scheme to defraud hundreds of District of Columbia nursing-home employees of at least $1.4 million in owed wages.[178]

In 2018, Winfrey began canvassing door-to-door for Georgia gubernatorial Democratic nominee Stacey Abrams.[179][180]

Winfrey is registered as an Independent.[181]

In 2018, Winfrey donated $500,000 to the March for Our Lives student demonstration in favor of gun control in the United States.[182] In early 2018, Winfrey met with Mohammad bin Salman, the crown prince and de facto ruler of Saudi Arabia.[183]

Spiritual leadership
In 2000, she was awarded the Spingarn Medal from the NAACP.[184] In 2002, Christianity Today published an article called "The Church of O" in which they concluded that Winfrey had emerged as an influential spiritual leader. "Since 1994, when she abandoned traditional talk-show fare for more edifying content, and 1998, when she began 'Change Your Life TV', Oprah's most significant role has become that of a spiritual leader. To her audience of more than 22 million mostly female viewers, she has become a postmodern priestess—an icon of church-free spirituality."[154] The sentiment was echoed by Marcia Z. Nelson in her book The Gospel According to Oprah.[185] Since the mid-1990s, Winfrey's show has emphasized uplifting and inspirational topics and themes and some viewers say the show has motivated them to perform acts of altruism such as helping Congolese women and building an orphanage.[186] A scientific study by psychological scientists at the University of Cambridge, University of Plymouth, and University of California used an uplifting clip from The Oprah Winfrey Show in an experiment that discovered that watching the 'uplifting' clip caused subjects to become twice as helpful as subjects assigned to watch a British comedy or nature documentary.[187][188]

In 1998, Winfrey began an ongoing conversation with Gary Zukav, an American spiritual teacher, who appeared on her television show 35 times.[189] Winfrey has said she keeps a copy of Zukav's The Seat of the Soul at her bedside, a book that she says is one of her all-time favorites.[190]

On the season premiere of Winfrey's 13th season, Roseanne Barr told Winfrey "you're the African Mother Goddess of us all" inspiring much enthusiasm from the studio audience. The animated series Futurama alluded to her spiritual influence by suggesting that "Oprahism" is a mainstream religion in 3000 AD.[191] Twelve days after the September 11 attacks, New York mayor Rudy Giuliani asked Winfrey to serve as host of a Prayer for America service at New York City's Yankee Stadium, which was attended by former president Bill Clinton and New York senator Hillary Clinton.[192] Leading up to the U.S.-led 2001 invasion of Afghanistan, less than a month after the September 11 attacks, Winfrey aired a controversial show called "Islam 101" in which she portrayed Islam as a religion of peace, calling it "the most misunderstood of the three major religions".[193] In 2002, George W. Bush invited Winfrey to join a US delegation that included adviser Karen Hughes and Condoleezza Rice, planning to go to Afghanistan to celebrate the return of Afghan girls to school. The "Oprah strategy" was designed to portray the War on Terror in a positive light; however, when Winfrey refused to participate, the trip was postponed.[194]

Leading up to the U.S.-led invasion of Iraq, Winfrey's show received criticism for allegedly having an anti-war bias. Ben Shapiro of Townhall.com wrote: "Oprah Winfrey is the most powerful woman in America. She decides what makes The New York Times Best Seller lists. Her touchy-feely style sucks in audiences at the rate of 14 million viewers per day. But Oprah is far more than a cultural force, she's a dangerous political force as well, a woman with unpredictable and mercurial attitudes toward the major issues of the day."[195] In 2006, Winfrey recalled such controversies: "I once did a show titled Is War the Only Answer? In the history of my career, I've never received more hate mail – like 'Go back to Africa' hate mail. I was accused of being un-American for even raising the question."[196] Filmmaker Michael Moore came to Winfrey's defense, praising her for showing antiwar footage no other media would show[197] and begging her to run for president.[198]

A February 2003 series, in which Winfrey showed clips from people all over the world asking America not to go to war, was interrupted in several East Coast markets by network broadcasts of a press conference in which President George W. Bush and Colin Powell summarized the case for war.[199][200]

In 2007, Winfrey began to endorse the self-help program The Secret. The Secret claims that people can change their lives through positive thoughts or 'vibrations', which will then cause them to attract more positive vibrations that result in good things happening to them. Peter Birkenhead of Salon magazine argued that this idea is pseudoscience and psychologically damaging, as it trivializes important decisions and promotes a quick-fix material culture, and suggests Winfrey's promotion of it is irresponsible given her influence.[201] In 2007, skeptic and magician James Randi accused Winfrey of being deliberately deceptive and uncritical in how she handles paranormal claims on her show.[202] In 2008, Winfrey endorsed author and spiritual teacher Eckhart Tolle and his book, A New Earth: Awakening to Your Life's Purpose, which sold several million extra copies after being selected for her book club. During a Webinar class, in which she promoted the book, Winfrey stated "God is a feeling experience and not a believing experience. If your religion is a believing experience [...] then that's not truly God."[203] Frank Pastore, a Christian radio talk show host on KKLA, was among the many Christian leaders who criticized Winfrey's views, saying "if she's a Christian, she's an ignorant one because Christianity is incompatible with New Age thought."[203]

Winfrey was named as the 2008 Person of the Year by animal-rights group People for the Ethical Treatment of Animals (PETA) for using her fame and listening audience to help the less fortunate, including animals. PETA praised Winfrey for using her talk show to uncover horrific cases of cruelty to animals in puppy mills and on factory farms, and Winfrey even used the show to highlight the cruelty-free vegan diet that she tried.[204] Winfrey also refuses to wear fur or feature it in her magazine
In 2009, Winfrey filmed a series of interviews in Denmark highlighting its citizens as the happiest people in the world. In 2010, Bill O'Reilly of Fox News criticized these shows for promoting a left-wing society.[206] Following the launch of the Super Soul Sunday and SuperSoul Sessions programs on Harpo Productions' SuperSoul TV, in 2016 Winfrey selected 100 people for the SuperSoul 100' list of "innovators and visionaries who are aligned on a mission to move humanity forward."[207][208]

On using the N-word, Winfrey said, "You cannot be my friend and use that word around me. ... I always think of the...people who heard that as their last word as they were hanging from a tree."[209]

Fan base
The viewership for The Oprah Winfrey Show was highest during the 1991–92 season, when about 13.1 million U.S. viewers were watching each day. By 2003, ratings declined to 7.4 million daily viewers.[210] Ratings briefly rebounded to approximately 9 million in 2005 and then declined again to around 7.3 million viewers in 2008, though it remained the highest rated talk show.[211]

In 2008, Winfrey's show was airing in 140 countries internationally and seen by an estimated 46 million people in the US weekly.[212][213] According to the Harris poll, Winfrey was America's favorite television personality in 1998, 2000, 2002–06, and 2009. Winfrey was especially popular among women, Democrats, political moderates, Baby Boomers, Generation X, Southern Americans, and East Coast Americans.[214]

Outside the U.S., Winfrey has become increasingly popular in the Arab world. The Wall Street Journal reported in 2007 that MBC 4, an Arab satellite channel, centered its entire programming around reruns of her show because it was drawing record numbers of female viewers in Saudi Arabia.[215] In 2008, The New York Times reported that The Oprah Winfrey Show, with Arabic subtitles, was broadcast twice each weekday on MBC 4. Winfrey's modest dress, combined with her attitude of triumph over adversity and abuse has caused some women in Saudi Arabia to idealize her

Selfridges

Selfridges

Selfridges, also known as Selfridges & Co., is a chain of high-end department stores in the United Kingdom that is operated by Selfridges Retail Limited, part of the Selfridges Group of department stores.[1] It was founded by Harry Gordon Selfridge in 1908.[1] The flagship store on London's Oxford Street is the second largest shop in the UK (after Harrods) and opened 15 March 1909.[4] Other Selfridges stores opened in the Trafford Centre (1998) and Exchange Square (2002) in Manchester, and in the Bullring in Birmingham (2003).

In the 1940s, smaller provincial Selfridges stores were sold to the John Lewis Partnership, and in 1951, the original Oxford Street store was acquired by the Liverpool-based Lewis's chain of department stores.[5] Lewis's and Selfridges were then taken over in 1965 by the Sears Group, owned by Charles Clore.[6] Expanded under the Sears Group to include branches in Manchester and Birmingham,[7] the chain was acquired in 2003 by Canada's Galen Weston for £598 million.[8]

The shop's early history was dramatised in ITV's 2013 series, Mr Selfridge
The basis of Harry Gordon Selfridge's success was his relentlessly innovative marketing, which was elaborately expressed in his Oxford Street store. Originally from America himself, Selfridge attempted to dismantle the idea that consumerism was strictly an American phenomenon.[10] He tried to make shopping a fun adventure and a form of leisure instead of a chore,[11] transforming the department store into a social and cultural landmark that provided women with a public space in which they could be comfortable and legitimately indulge themselves.[10] Emphasizing the importance of creating a welcoming environment, he placed merchandise on display so customers could examine it, moved the highly profitable perfume counter front-and-centre on the ground floor, and established policies that made it safe and easy for customers to shop. These techniques have been adopted by modern department stores around the world.

Either Selfridge or Marshall Field is popularly held to have coined the phrase "the customer is always right",[12] and Selfridge used it regularly in his advertising.
Selfridge attracted shoppers with educational and scientific exhibits and was himself interested in education and science, believing that the displays would introduce potential new customers to Selfridges and thus generate both immediate and long-term sales.

In 1909, after the first cross-Channel flight, Louis Blériot's monoplane was put on display at Selfridges, where it was seen by 12,000 people. John Logie Baird made the first public demonstration of moving silhouette images by television from the first floor of Selfridges from 1 to 27 April 1925.[13]

In the 1920s and 1930s, the roof of the store hosted terraced gardens, cafes, a mini golf course and an all-girl gun club. The roof, with its extensive views across London, was a common place for strolling after a shopping trip and was often used for fashion shows.[citation needed] During the Second World War, The store's basement was used as an air-raid shelter and during raids employees were usually on the lookout for incendiary bombs and took watch in turns.[14] The store was bombed but survived comparatively unscathed except for the famous roof gardens, which were destroyed and not reopened[15] until 2009.

A Milne-Shaw seismograph was set up on the Oxford Street store's third floor in 1932, attached to one of the building's main stanchions, where it remained unaffected by traffic or shoppers. It successfully recorded the Belgian earthquake of 11 June 1938, which was also felt in London. In 1947, it was given to the British Museum. The huge SIGSALY scrambling apparatus, by which transatlantic conferences between American and British officials (most notably Winston Churchill and Franklin D. Roosevelt) were secured against eavesdropping, was housed in the basement from 1943 on, with extension to the Cabinet War Rooms about a mile away
In 1926, Selfridges set up the Selfridge Provincial Stores company, which had expanded over the years to include sixteen provincial stores, but these were sold to the John Lewis Partnership in 1940. The Liverpool-based Lewis's chain of department stores acquired the remaining Oxford Street Shop in 1951, until it was taken over in 1965 by the Sears Group, owned by Charles Clore.[6] Under the Sears group, branches in Ilford and Oxford opened, with the latter remaining Selfridges until 1986, when Sears rebranded it as a Lewis's store. In 1990, Sears Holdings split Selfridges from Lewis's and placed Lewis's in administration a year later. In March 1998, Selfridges acquired its current logo in tandem with the opening of the Manchester Trafford Centre store and Selfridges' demerger from Sears.

In September 1998, Selfridges expanded and opened a department store in the newly-opened Trafford Centre in Greater Manchester. Following its success, Selfridges announced they would open an additional 125,000-square-foot (11,600 m2) store in Exchange Square, Manchester city centre. The Exchange Square store opened in 2002 as Manchester city centre started to return to normal following the 1996 Manchester bombing. A 260,000-square-foot (24,000 m2)[7] store opened in 2003 in Birmingham's Bull Ring.
In 2003, the chain was acquired by Canada's Galen Weston for £598 million and became part of Selfridges Group, which also includes Brown Thomas and Arnotts in Ireland, Holt Renfrew in Canada and de Bijenkorf in the Netherlands. Weston, a retailing expert who is also the owner of major supermarket chains in Canada, has chosen to invest in the renovation of the Oxford Street store – rather than to create new stores in British cities other than Manchester and Birmingham.[17] Simon Forster is the Managing Director of Selfridges, while Anne Pitcher is the Managing Director of Selfridges Group.[citation needed]

In October 2009, Selfridges revived its rooftop entertainment with the opening of "The Restaurant on the Roof".[clarification needed] In July 2011, Truvia created an emerald green boating lake (with a waterfall, a boat-up cocktail bar and a forest of Stevia plants).[clarification needed] In 2012 the Big Rooftop Tea and Golf Party featured "the highest afternoon tea on Oxford Street" and a nine-hole golf course with "the seven wonders of London" realised in cake as obstacles.[18]

Architecture
Selfridge stores are known for architectural innovation and excellence, and are tourist destinations in their own right.[citation needed] The original London store was designed by Daniel Burnham, who also created the Marshall Field's main store in his home town of Chicago. Burnham was the leading American department store designer of the time and had works in Boston (Filenes's), New York (Gimbel's, Wanamaker's), and Philadelphia (Wanamaker's, his magnum opus).[19]
The London store was built in phases. The first phase consisted of only the nine-and-a-half bays closest to the Duke Street corner,[20] and is an example of one of the earliest uses of steel cage frame construction for this type of building in London. This circumstance, according to the report of a contemporary London correspondent from the Chicago Tribune, was largely responsible for making possible the eventual widespread use of Chicago’s steel frame cage construction system in the United Kingdom. “Under the pressure of [Mr. Selfridge] and the interests allied with him, the councilors admitted the soundness of American building methods and framed a bill which will be pressed at once in parliament [sic] to permit these methods to be used here.”.[21] A scheme to erect a massive tower above the store was never carried out.
Also involved in the design of the store were American architect Francis Swales, who worked on decorative details, and British architects R. Frank Atkinson and Thomas Smith Tait.[22][23] The distinctive polychrome sculpture above the Oxford Street entrance is the work of British sculptor Gilbert Bayes.
The Daily Telegraph named Selfridges in London the world's best department store in 2010
The Trafford store is noted for its use of stone and marble and for the exterior which strikingly resembles the London store. Each of the five floors of the Exchange Square store in central Manchester was designed by a different architect and has its own look and feel. In December 2009, store officials announced that the store will undergo a £40 million renovation to give it a more iconic look that has been associated with Selfridges. It has been announced the store will feature art installations using LED lighting that will be projected to the outside of the building at night.[citation needed]

The Birmingham store, designed by architects Future Systems, is covered in 15,000 spun aluminium discs on a background of Yves Klein Blue.[25] Since it opened in 2003, the Birmingham store has been named every year by industry magazine Retail Week as one of the 100 stores to visit in the world.[26] The building is also included as a desktop background in the Architecture theme in Windows 7.

Windows
Selfridges' windows have become synonymous also with the brand, and to a certain degree have become as famous as the company and Oxford Street location itself. Selfridges has a history of bold art initiatives when it comes to the window designs. Selfridge himself likened the act of shopping to the act of attending the theater and encouraged his customers to make this connection as well by covering his show windows with silk curtains before dramatically unveiling the displays on opening day.[10] Just as they do today, the window designs served as the opening act of the entire play of the Selfridge experience and helped capture the public’s attention to transform customers into true shoppers. Later, when the building was undergoing restoration, the scaffolding was shrouded with a giant photograph of stars such as Sir Elton John by Sam Taylor-Wood. The windows consistently attract tourists, designers and fashionistas alike to marvel at the current designs and styling and fashion trends.

Since 2002, the windows have been photographed by London photographer Andrew Meredith and published in magazines such as Vogue, Dwell, Icon, Frame, Creative Review, Hungarian Stylus Magazine, Design Week, Harper's Bazaar, The New York Times, WGSN as well as many worldwide media outlets, including the world wide press, journals, blogs and published books.[27]

Opening day and marketing
The long lasting influence that Harry Selfridge would have on shopping and department stores became immediately clear with Selfridges' opening day. The store’s opening to much fanfare on 15 March 1909 laid the foundation for the success of the entire lifestyle that Selfridge aimed to promote. Even before the unveiling of the window displays, innovative marketing techniques set up the momentous occasion and the store for great success.[28]

Harry Selfridge developed close relationships with the media to ensure that his store and its opening were properly publicized.[10] The opening week ad campaign relied mainly on unpaid promotions in the form of news articles in newspapers, magazines, and journals. As time progressed, Selfridge took the more traditional form of marketing by writing daily columns under the pen name Callisthenes.[10] Overall, however, one of the most effective marketing tools proved to be the opening week cartoons focusing on the grand event. Selfridge enlisted the help of thirty-eight of London’s top illustrators to draw hundreds of full page, half page, and quarter page advertisements for eighteen newspapers.[29] This innovative combination of direct advertisements and newspaper publicities proved to be quite effective at drawing the crowds to the store.

The marketing continued on opening day itself. Touted as “London’s Greatest Store,” Selfridges immediately became a cultural and social phenomenon. From the store's soft lighting to the general absence of price tags to live music from string quartets, every detail of the opening was purposeful to draw people into the entire shopping experience and make each shopper feel unique.[29] At Selfridges, shoppers entered another world in which they became "guests," as the store referred to them, and could purchase unique items that differed from the material goods sold in other stores.[29] The successes of the marketing campaign and the store’s opening day highlight that Selfridges sold an entire lifestyle, not just an impressive array of material products.

Controversies
After protests by animal welfare advocates,[30][31][32] in November 2009 Selfridges agreed to stop selling foie gras[33] (a delicacy made from the livers of forcibly fattened ducks and geese) and banished from its food court a celebrity butcher who had continued to sell foie gras under the codename "French fillet".[34]
In July 2010, Selfridges apologized publicly after its Manchester store displayed an Alexander McQueen garment hanging from a gallows-like structure, just months after the designer committed suicide by hanging.[35]
In September 2013, the store suspended a shop assistant who refused to serve a friend of English Defence League leader Tommy Robinson.[36][37]
In February 2015, one of Selfridges' stores in Manchester installed so-called anti-homeless spikes.[38]
In culture
ITV and Masterpiece produced a series entitled Mr Selfridge, first airing on ITV beginning in January 2013 (in ten parts), and later on PBS starting on 30 March 2013 (in eight parts).[39] ITV began airing ten additional episodes in January 2014.[40] The fourth series began in 2016 with the first episode airing on 8 January 2016.[40]

Selfridges was also featured in the 2017 movie Wonder Woman as the shop where Steve Trevor takes Diana Prince to give her a more contemporary appearance to blend in.

Eurovision 2020

Eurovision 2020

The Eurovision Song Contest 2020 was planned to be the 65th edition of the Eurovision Song Contest. The contest would have taken place in Rotterdam, Netherlands, following the country's victory at the 2019 contest in Tel Aviv, Israel, with the song "Arcade" performed by Duncan Laurence. This would have been the fifth time that the Netherlands hosted the contest, the last edition having been the 1980 contest, and the first Eurovision event to be hosted in the country since the Junior Eurovision Song Contest 2012. The contest would have been held at Rotterdam Ahoy. It was originally scheduled to consist of two semifinals on 12 and 14 May, and a final on 16 May 2020.[1] Forty-one countries would have participated in the contest. Bulgaria and Ukraine would have returned after their absences from the 2019 contest, while Hungary and Montenegro confirmed their non-participation after taking part in the previous edition. However, on 18 March 2020, the European Broadcasting Union (EBU) announced that the event cancelled due to 2020 coronavirus pandemic in Europe.[2]
The 2020 contest was to be held at Rotterdam Ahoy in Rotterdam, Netherlands. It would have been the fifth time the Netherlands hosts the contest, following the country's victory at the 2019 edition with the song "Arcade", performed by Duncan Laurence. Rotterdam Ahoy had previously hosted the Junior Eurovision Song Contest 2007.[3]

Preparations
Preparations for the 2020 contest began on 19 May 2019, immediately after the Netherlands won the 2019 contest in Tel Aviv, Israel. Jon Ola Sand, the executive supervisor of the European Broadcasting Union (EBU) for the contest, handed AVROTROS, the Dutch participating broadcaster, a stack of documents and a USB drive with tools to begin the work needed to host the next contest.[4] AVROTROS was co-organising the event with sister broadcaster Nederlandse Omroep Stichting (NOS) and their parent public broadcasting organisation, Nederlandse Publieke Omroep (NPO).[5][6]

Bidding phase
Eurovision Song Contest 2020 is located in NetherlandsArnhemArnhem's-Hertogen- bosch's-Hertogen-
boschMaastrichtMaastrichtRotterdamRotterdamUtrechtUtrecht
Locations of the candidate cities: the chosen host city is marked in blue. The shortlisted cities are marked in green, while the eliminated cities are marked in red.
Already prior to the 2019 contest, when bookmakers expected Laurence to win, several Dutch cities, including Amsterdam, The Hague and Maastricht, announced their intent to host the contest should Laurence win.[7] A spokesperson for NPO also stated that the broadcaster had a rough plan for how they would select the host city in the event of a Dutch victory.[8] When Laurence won the contest, mayors of various municipalities immediately began lobbying Mark Rutte, the Prime Minister of the Netherlands, through text messages.[9] Public figures, including Laurence, Esther Hart, Getty Kaspers and André Rieu, publicly voiced their support for their respective favourite host cities.[10]

The hosting broadcasters launched the bidding process on 29 May 2019.[11] In the first phase of this process, cities were to formally apply to bid.[12] Nine cities—Amsterdam, Arnhem, Breda, 's-Hertogenbosch, The Hague, Leeuwarden, Maastricht, Rotterdam, and Utrecht—did so and received a list of criteria they and their venues needed to meet on 12 June 2019.[12] Initially, Zwolle had also considered launching a bid to host the event but the city ultimately decided against doing so because it deemed its venue, the IJsselhallen, to have unsuitable proportions.[13] Enschede could have been a potential host city as Enschede Airport Twente considered bidding to host the event in its eleventh hangar, however, it later learned that Enschede's municipality executive board had decided against financially supporting such a bid.[14][15]

From this point on, these nine cities had until 10 July 2019 to compile their bid books to demonstrate their capabilities to host the contest.[12] Further cities were still able to join in on the bidding race by applying prior to the deadline.[12] During this period, four cities withdrew. Amsterdam could not host the contest because it was preoccupied with hosting other events during the contest's time frame.[16] Breda dropped out due to financial concerns.[17] Leeuwarden ceased bidding due to the insufficient height of the ceiling of its WTC Expo.[18] The Hague dropped its bid because both of its potential venues were unsuitable for the event.[19] The local Cars Jeans Stadion football stadium would have been large enough but lacked a roof, and installing such a roof would have made the bid financially unviable.[19] Its other option would have been spanning a tent over the Malieveld field, but after reviewing the hosting conditions, this option fell out of favour.[19] Following its withdrawal, The Hague turned to support Rotterdam's bid instead.[19]

The five remaining cities—Arnhem, 's-Hertogenbosch, Maastricht, Rotterdam, and Utrecht—delivered their finished bid books to a ceremonial event held in Hilversum on 10 July 2019.[20] The hosting broadcasters reviewed the bids presented and on 16 July 2019 announced that it eliminated those for Arnhem, 's-Hertogenbosch and Utrecht, shortlisting only Maastricht and Rotterdam.[21] Utrecht was specifically eliminated because its proposal to span a tent over its Jaarbeurs offered limited possibilities for testing on location and had a questionable suitability for events like the Eurovision Song Contest,[22] while 's-Hertogenbosch was dropped due to an insufficient ceiling height in its Brabanthallen and too few hotel rooms blocked for potential visitors of the contest.[23]

To review and discuss the location, venue and surrounding events for the remaining bids, NPO visited Maastricht on 17 July 2019 and Rotterdam on the following day.[24][25] By late July, additional visits to the two shortlisted cities were deemed necessary to review production logistics.[26] The EBU did not pay visits to either city.[27] Maastricht and Rotterdam were to hand in revised versions of their bid books by 9 August 2019 to add details involving the cities' social programmes, side-events and programme licensing.[28] A "concept agreement" was put before the organisers in both Maastricht and Rotterdam in August 2019.[29] While Rotterdam signed this agreement, the city council of Maastricht discussed and rejected it.[29] Within the same council session, it was also clarified that the MECC would not receive additional renovations.[29] On 30 August, Rotterdam was announced as the host city during a special broadcast on NPO 1 and NPO 2.

EastEnders

EastEnders

 is a British soap opera created by Julia Smith and Tony Holland which has been broadcast on BBC One since 1985. Set in Albert Square in the East End of London in the fictional Borough of Walford, the programme follows the stories of local residents and their families as they go about their daily lives. Initially there were two 30-minute episodes per week, later increasing to three, but since 2001, episodes have been broadcast on every weekday except Wednesday (outside of special occasions). This was reduced again to two episodes a week in March 2020, on Monday and Tuesday evenings, due to the 2019–20 coronavirus pandemic, which caused production to halt.

Within eight months of the show's launch, it reached the number one spot in BARB's TV ratings and has consistently remained among the top rated series in Britain. In 2013, the average audience share for an episode was around 30 per cent.[3] Today, EastEnders remains a significant programme in terms of the BBC's success and audience share, and also in the history of British television drama, tackling many dilemmas that are considered to be controversial and taboo issues in British culture and social life previously unseen on UK mainstream television.[4]

As of September 2019, EastEnders has won ten BAFTA Awards and the Inside Soap Award for Best Soap for 14 years running (from 1997 to 2012),[5] as well as twelve National Television Awards for Most Popular Serial Drama[6] and 11 awards for Best British Soap at the British Soap Awards. It has also won 13 TV Quick and TV Choice Awards for Best Soap, six TRIC Awards for Soap of The Year, four Royal Television Society Awards for Best Continuing Drama and has been inducted into the Rose d'Or Hall of Fame
History
Conception and preparations for broadcast
In March 1983, under two years before EastEnders' first episode was broadcast, the show was a vague idea in the mind of a handful of BBC executives, who decided that what BBC1 needed was a popular bi-weekly drama series that would attract the kind of mass audiences that ITV was getting with Coronation Street.[8] The first people to whom David Reid, then head of series and serials, turned were Julia Smith and Tony Holland, a well established producer/script editor team who had first worked together on Z-Cars.[8] The outline that Reid presented was vague: two episodes a week, 52 weeks a year.[9] After the concept was put to them on 14 March 1983, Smith and Holland then went about putting their ideas down on paper; they decided it would be set in the East End of London.[8] Granada Television gave Smith unrestricted access to the Coronation Street production for a month so that she could get a sense how a continuing drama was produced.[10]

There was anxiety at first that the viewing public would not accept a new soap set in the south of England, though research commissioned by lead figures in the BBC revealed that southerners would accept a northern soap, northerners would accept a southern soap and those from the Midlands, as Julia Smith herself pointed out, did not mind where it was set as long as it was somewhere else.[9] This was the beginning of a close and continuing association between EastEnders and audience research, which, though commonplace today, was something of a revolution in practice.[9]

The show's creators were both Londoners, but when they researched Victorian squares, they found massive changes in areas they thought they knew well. However, delving further into the East End of London, they found exactly what they had been searching for: a real East End spirit—an inward-looking quality, a distrust of strangers and authority figures, a sense of territory and community that the creators summed up as "Hurt one of us and you hurt us all".[9]

When developing EastEnders, both Smith and Holland looked at influential models like Coronation Street, but they found that it offered a rather outdated and nostalgic view of working-class life. Only after EastEnders began, and featured the characters of Tony Carpenter and Kelvin Carpenter, did Coronation Street start to feature black characters, for example.[11] They came to the conclusion that Coronation Street had grown old with its audience, and that EastEnders would have to attract a younger, more socially extensive audience, ensuring that it had the longevity to retain it for many years thereafter.[12] They also looked at Brookside but found there was a lack of central meeting points for the characters, making it difficult for the writers to intertwine different storylines, so EastEnders was set in Albert Square.[13]

A previous UK soap set in an East End market was ATV's Market in Honey Lane between 1967 and 1969. However this show, which graduated from one showing a week to two in three separate series (the latter series being shown in different time slots across the ITV network) was very different in style and approach to EastEnders. The British Film Institute described Market In Honey Lane thus: "It was not an earth-shaking programme, and certainly not pioneering in any revolutionary ideas in technique and production, but simply proposed itself to the casual viewer as a mildly pleasant affair."[14] EastEnders, while also featuring an East End street market, would be very different in its approach and impact.

The target launch date was originally January 1985.[15] Smith and Holland had eleven months in which to write, cast and shoot the whole thing. However, in February 1984, they did not even have a title or a place to film. Both Smith and Holland were unhappy about the January 1985 launch date, favouring November or even September 1984 when seasonal audiences would be higher, but the BBC stayed firm, and Smith and Holland had to concede that, with the massive task of getting the Elstree Studios operational, January was the most realistic date. However, this was later to be changed to February.[15]

The project had a number of working titles—Square Dance, Round the Square, Round the Houses, London Pride and East 8.[16] It was the latter that stuck (E8 is the postcode for Hackney) in the early months of creative process.[17] However, the show was renamed after many casting agents mistakenly thought the show was to be called Estate, and the fictional postcode E20 was created, instead of using E8.[17] Julia Smith came up with the name Eastenders after she and Holland had spent months telephoning theatrical agents and asking "Do you have any real East Enders on your books?"[17] However, Smith thought "Eastenders" "looked ugly written down" and was "hard to say", so decided to capitalise the second 'e'.[17]

Initial character creation and casting
After they decided on the filming location of BBC Elstree Centre in Hertfordshire, Smith and Holland set about creating the 23 characters needed, in just 14 days.[18] They took a holiday in Playa de los Pocillos, Lanzarote, and started to create the characters.[19] Holland created the Beale and Fowler family, drawing on his own background. His mother, Ethel Holland, was one of four sisters raised in Walthamstow. Her eldest sister, Lou, had married a man named Albert Beale and had two children, named Peter and Pauline.[20] These family members were the basis for Lou Beale, Pete Beale and Pauline Fowler. Holland also created Pauline's unemployed husband Arthur Fowler, their children Mark Fowler and Michelle Fowler, Pete's wife Kathy Beale and their son Ian Beale.[21] Smith used her personal memories of East End residents she met when researching Victorian squares.[22] Ethel Skinner was based on an old woman she met in a pub, with ill-fitting false teeth, and a "face to rival a neon sign", holding a Yorkshire Terrier in one hand and a pint of Guinness in the other.[23] Other characters created included Jewish doctor Harold Legg, the Anglo-Cypriot Osman family, Ali Osman, Sue Osman and baby Hassan Osman, black father and son, Tony Carpenter and Kelvin Carpenter, single mother Mary Smith and Bangladeshi couple Saeed Jeffery and Naima Jeffery. Jack, Pearl and Tracey Watts were created to bring "flash, trash, and melodrama" to the Square (they were later renamed Den, Angie and Sharon Watts). The characters of Andy O'Brien and Debbie Wilkins were created to show a modern couple with outwardly mobile pretensions, and Lofty Holloway to show an outsider; someone who did not fit in with other residents. It was decided that he would be a former soldier, as Holland's personal experiences of ex-soldiers were that they had trouble fitting into society after being in the army. When they compared the characters they had created, Smith and Holland realised they had created a cross-section of East End residents. The Beale and Fowler family represented the old families of the East End, who had always been there. The Osmans, Jefferys and Carpenters represented the more modern diverse ethnic community of the East End. Debbie, Andy and Mary represented more modern-day individuals.[12]

Once they had decided on their 23 characters, they returned to London for a meeting with the BBC. Everyone agreed that EastEnders would be tough, violent on occasion, funny and sharp—set in Margaret Thatcher's Britain—and it would start with a bang (namely the death of Reg Cox). They decided that none of their existing characters were wicked enough to have killed Reg, so a 24th character, Nick Cotton was added to the line-up. He was a racist thug, who often tried to lead other young characters astray.[24] When all the characters had been created, Smith and Holland set about casting the actors for the show.

Final preparations
Through the next few months, the set was growing rapidly at Elstree, and a composer and designer had been commissioned to create the title sequence. Simon May wrote the theme music[25] and Alan Jeapes created the visuals.[26] The visual images were taken from an aircraft flying over the East End of London at 1000 feet. Approximately 800 photographs were taken and pieced together to create one big image.[27] The credits were later updated when the Millennium Dome was built.[27]

The launch was delayed until February 1985[28] due to a delay in the chat show Wogan, that was to be a part of the major revamp in BBC1's schedules. Smith was uneasy about the late start as EastEnders no longer had the winter months to build up a loyal following before the summer ratings lull. The press were invited to Elstree to meet the cast and see the lot, and stories immediately started circulating about the show, about a rivalry with ITV (who were launching their own market-based soap, Albion Market) and about the private lives of the cast.[29] Anticipation and rumour grew in equal measure until the first transmission at 7 p.m. on 19 February 1985.[29] Both Holland and Smith could not watch; they both instead returned to the place where it all began, Albertine's Wine Bar on Wood Lane.[29] The next day, viewing figures were confirmed at 17 million.[29] The reviews were largely favourable,[29] although, after three weeks on air, BBC1's early evening share had returned to the pre-EastEnders figure of seven million, though EastEnders then climbed to highs of up to 23 million later on in the year.[30] Following the launch, both group discussions and telephone surveys were conducted to test audience reaction to early episodes. Detailed reactions were taken after six months and since then regular monitoring was conducted
1980s broadcast history
Press coverage of EastEnders, which was already intense, went into overdrive once the show was broadcast. With public interest so high, the media began investigating the private lives of the show's popular stars. Within days, a scandalous headline appeared – "EASTENDERS STAR IS A KILLER". This referred to Leslie Grantham, and his prison sentence for the murder of a taxi driver in an attempted robbery nearly 20 years earlier. This shocking tell-all style set the tone for relations between Albert Square and the press for the next 20 years.

The show's first episode attracted some 17 million viewers, and it continued to attract high viewing figures from then on.[31] By Christmas 1985, the tabloids could not get enough of the soap. 'Exclusives' about EastEnders storylines and the actors on the show became a staple of tabloid buyers’ daily reading.[citation needed]

Writer Colin Brake suggested that 1989 was a year of big change for EastEnders, both behind the cameras and in front of them. Original production designer, Keith Harris, left the show, and Holland and Smith both decided that the time had come to move on too; their final contribution coinciding with the exit of one of EastEnders' most successful characters, Den Watts (Leslie Grantham).[32] Producer Mike Gibbon was given the task of running the show and he enlisted the most experienced writers to take over the storylining of the programme, including Charlie Humphreys, Jane Hollowood and Tony McHale.[33]

According to Brake, the departure of two of the soap's most popular characters, Den and Angie Watts (Anita Dobson), left a void in the programme, which needed to be filled.[32] In addition, several other long-running characters left the show that year including Sue and Ali Osman (Sandy Ratcliff and Nejdet Salih) and their family; Donna Ludlow (Matilda Ziegler); Carmel Jackson (Judith Jacob) and Colin Russell (Michael Cashman). Brake indicated that the production team decided that 1989 was to be a year of change in Walford, commenting, "it was almost as if Walford itself was making a fresh start".[34]

By the end of 1989 EastEnders had acquired a new executive producer, Michael Ferguson, who had previously been a successful producer on ITV's The Bill. Brake suggested that Ferguson was responsible for bringing in a new sense of vitality and creating a programme that was more in touch with the real world than it had been over the previous year.[33]

Changes in the 1990s
A new era began in 1990 with the introduction of Phil Mitchell (Steve McFadden) and Grant Mitchell (Ross Kemp)—the Mitchell brothers—successful characters who would go on to dominate the soap thereafter.[35] As the new production team cleared the way for new characters and a new direction, all of the characters introduced under Gibbon were axed from the show at the start of the year.[36] Ferguson introduced other characters and was responsible for storylines including HIV, Alzheimer's disease and murder. After a successful revamp of the soap, Ferguson decided to leave EastEnders in July 1991.[37] Ferguson was succeeded by both Leonard Lewis and Helen Greaves who initially shared the role as Executive Producer for EastEnders.[38] Lewis and Greaves formulated a new regime for EastEnders, giving the writers of the serial more authority in storyline progression, with the script department providing "guidance rather than prescriptive episode storylines".[32] By the end of 1992, Greaves left and Lewis became executive and series producer.[39] He left EastEnders in 1994 after the BBC controllers demanded an extra episode a week, taking its weekly airtime from 60 to 90 minutes.[40] Lewis felt that producing an hour of "reasonable quality drama" a week was the maximum that any broadcasting system could generate without loss of integrity.[40] Having set up the transition to the new schedule, the first trio of episodes—dubbed The Vic siege—marked Lewis's departure from the programme.[41] Barbara Emile then became the Executive Producer of EastEnders,[42][43] remaining with EastEnders until early 1995. She was succeeded by Corinne Hollingworth.

Hollingworth's contributions to the soap were awarded in 1997 when EastEnders won the BAFTA for Best Drama Series. Hollingworth shared the award with the next Executive Producer, Jane Harris.[44] Harris was responsible for the critically panned Ireland episodes and Cindy Beale's attempted assassination of Ian Beale, which brought in an audience of 23 million in 1996, roughly four million more than Coronation Street.[45][46] In 1998 Matthew Robinson was appointed as the Executive Producer of EastEnders. During his reign, EastEnders won the BAFTA for "Best Soap" in consecutive years 1999 and 2000 and many other awards. Robinson also earned tabloid soubriquet "Axeman of Albert Square" after sacking a large number of characters in one hit, and several more thereafter. In their place, Robinson introduced new long-running characters including Melanie Healy, Jamie Mitchell, Lisa Shaw, Steve Owen and Billy Mitchell.

2000s
John Yorke became the Executive Producer of EastEnders in 2000. Yorke was given the task of introducing the soap's fourth weekly episode. He axed the majority of the Di Marco family and helped introduce popular characters such as the Slater family. As what Mal Young described as "two of EastEnders' most successful years", Yorke was responsible for highly rated storylines such as "Who Shot Phil?", Ethel Skinner's death, Jim Branning and Dot Cotton's marriage, Trevor Morgan's domestic abuse of his wife Little Mo Morgan, and Kat Slater's revelation to her daughter Zoe Slater that she was her mother.

In 2002, Louise Berridge succeeded Yorke as the Executive Producer. During her time at EastEnders, Berridge introduced popular characters such as Alfie Moon, Dennis Rickman,[47] Chrissie Watts, Jane Beale, Stacey Slater[48] and the critically panned Indian Ferreira family.[49]

Berridge was responsible for some ratings success stories, such as Alfie and Kat Slater's relationship, Janine Butcher getting her comeuppance, Trevor Morgan and Jamie Mitchell's death storylines and the return of one of the greatest soap icons, Den Watts, who had been presumed dead for 14 years. His return in late 2003 was watched by over 16 million viewers, putting EastEnders back at number one in the rating war with the Coronation Street.[50] However, other storylines, such as one about a kidney transplant involving the Ferreiras, were not well received,[49] and although Den Watts's return proved to be a ratings success, the British press branded the plot unrealistic and felt that it questioned the show's credibility.[51] A severe press backlash followed after Den's actor, Leslie Grantham, was outed in an internet sex scandal, which coincided with a swift decline in viewer ratings.[49] The scandal led to Grantham's departure from the soap, but the occasion was used to mark the 20th anniversary of EastEnders, with an episode showing Den's murder at the Queen Vic pub.

On 21 September 2004, Berridge quit as executive producer of EastEnders following continued criticism of the show. Kathleen Hutchison was swiftly appointed as the Executive Producer of EastEnders, and was tasked with quickly turning the fortunes of the soap. During her time at the soap Hutchison axed multiple characters, and reportedly ordered the rewriting of numerous scripts. Newspapers reported on employee dissatisfaction with Hutchison's tenure at EastEnders.[52] In January 2005, Hutchison left the soap and John Yorke (who by this time, was the BBC Controller of Continuing Drama Series) took total control of the show himself and became acting Executive Producer for a short period, before appointing Kate Harwood to the role.[53] Harwood stayed at EastEnders for 20 months before being promoted by the BBC. The highly anticipated return of Ross Kemp as Grant Mitchell in October 2005 proved to be a sudden major ratings success, with the first two episodes consolidating to ratings of 13.21 to 13.34 million viewers.[54][55] On Friday 11 November 2005, EastEnders was the first British drama to feature a two-minute silence.[56] This episode later went on to win the British Soap Award for 'Best Single Episode'.[57] In October 2006, Diederick Santer took over as Executive Producer of EastEnders. He introduced several characters to the show, including ethnic minority and homosexual characters to make the show 'feel more 21st Century'. Santer also reintroduced past and popular characters to the programme.

On 2 March 2007, BBC signed a deal with Google to put videos on YouTube. A behind the scenes video of EastEnders, hosted by Matt Di Angelo, who played Deano Wicks on the show, was put on the site the same day,[58] and was followed by another on 6 March 2007.[59] In April 2007, EastEnders became available to view on mobile phones, via 3G technology, for 3, Vodafone and Orange customers.[60] On 21 April 2007, the BBC launched a new advertising campaign using the slogan "There's more to EastEnders".[61] The first television advert showed Dot Branning with a refugee baby, Tomas, whom she took in under the pretence of being her grandson.[62] The second and third featured Stacey Slater and Dawn Swann, respectively.[63][64] There have also been adverts in magazines and on radio.

In 2009, producers introduced a limit on the number of speaking parts in each episode due to budget cuts, with an average of 16 characters per episode. The decision was criticised by Martin McGrath of Equity, who said: "Trying to produce quality TV on the cheap is doomed to fail." The BBC responded by saying they had been working that way for some time and it had not affected the quality of the show.[65]

2010s
From 4 February 2010, CGI was used in the show for the first time, with the addition of computer-generated trains.[66]

EastEnders celebrated its 25th anniversary on 19 February 2010. Santer came up with several plans to mark the occasion, including the show's first episode to be broadcast live, the second wedding between Ricky Butcher and Bianca Jackson and the return of Bianca's relatives, mother Carol Jackson, and siblings Robbie Jackson, Sonia Fowler and Billie Jackson. He told entertainment website Digital Spy, "It's really important that the feel of the week is active and exciting and not too reflective. There'll be those moments for some of our longer-serving characters that briefly reflect on themselves and how they've changed. The characters don't know that it's the 25th anniversary of anything, so it'd be absurd to contrive too many situations in which they're reflective on the past. The main engine of that week is great stories that'll get people talking."[67] The live episode featured the death of Bradley Branning (Charlie Clements) at the conclusion of the "Who Killed Archie?" storyline, which saw Bradley's wife Stacey Slater (Lacey Turner) reveal that she was the murderer. Viewing figures peaked at 16.6 million, which was the highest viewed episode in seven years.[68] Other events to mark the anniversary were a spin-off DVD, EastEnders: Last Tango in Walford, and an Internet spin-off, EastEnders: E20.
Santer officially left EastEnders in March 2010, and was replaced by Bryan Kirkwood. Kirkwood's first signing was the reintroduction of characters Alfie Moon (Shane Richie) and Kat Moon (Jessie Wallace),[69] and his first new character was Vanessa Gold, played by Zöe Lucker.[70] In April and May 2010, Kirkwood axed eight characters from the show,[71][72] Barbara Windsor left her role of Peggy Mitchell, which left a hole in the show, which Kirkwood decided to fill by bringing back Kat and Alfie, which he said would "herald the new era of EastEnders."[73][74] EastEnders started broadcasting in high definition on 25 December 2010.[75] Old sets had to be rebuilt, so The Queen Victoria set was burnt down in a storyline (and in reality) to facilitate this.

In November 2011, a storyline showed character Billy Mitchell, played by Perry Fenwick, selected to be a torch bearer for the 2012 Summer Olympics. In reality, Fenwick carried the torch through the setting of Albert Square, with live footage shown in the episode on 23 July 2012. This was the second live broadcast of EastEnders.[citation needed] In 2012, Kirkwood chose to leave his role as executive producer and was replaced by Lorraine Newman. The show lost many of its significant characters during this period. Newman stepped down as executive producer after 16 months in the job in 2013 after the soap was criticised for its boring storylines and its lowest-ever figures pointing at around 4.8 million.[76] Dominic Treadwell-Collins was appointed as the new executive producer on 19 August 2013[77][78] and was credited on 9 December.[79] He axed multiple characters from the show[80] and introduced the extended Carter family.[81] He also introduced a long-running storyline, "Who Killed Lucy Beale?", which peaked during the show's 30th anniversary in 2015 with a week of live episodes.[82] Treadwell-Collins announced his departure from EastEnders on 18 February 2016.[83]

Sean O'Connor, former EastEnders series story producer and then-editor on radio soap opera The Archers, was announced to be taking over the role.[84] Treadwell-Collins left on 6 May[85] and O'Connor's first credited episode was broadcast on 11 July[86] Although O'Connor's first credited episode aired in July, his own creative work was not seen onscreen until late September.[87] Additionally, Oliver Kent was brought in as the Head of Continuing Drama Series for BBC Scripted Studios, meaning that Kent would oversee EastEnders along with O'Connor.[88] O'Connor's approach to the show was to have a firmer focus on realism, which he said was being "true to EastEnders' DNA and [finding] a way of capturing what it would be like if Julia Smith and Tony Holland were making the show now." He said that "EastEnders has always had a distinctly different tone from the other soaps but over time we've diluted our unique selling point. I think we need to be ourselves and go back to the origins of the show and what made it successful in the first place. It should be entertaining but it should also be informative—that's part of our unique BBC compact with the audience. It shouldn't just be a distraction from your own life, it should be an exploration of the life shared by the audience and the characters."[89] O'Connor planned to stay with EastEnders until the end of 2017, but announced his departure on 23 June 2017 with immediate effect,[90] saying he wanted to concentrate on a career in film. John Yorke returned as a temporary executive consultant. Kent said, "John Yorke is a Walford legend and I am thrilled that he will be joining us for a short period to oversee the show and to help us build on Sean's legacy while we recruit a long-term successor."[91] Yorke initially returned for three months but his contract was later extended.[92] In July 2018, a special episode was aired as part of a knife crime storyline. This episode, which showed the funeral of Shakil Kazemi (Shaheen Jafargholi) interspersed with real people talking about their true-life experiences of knife crime. [93]

On 8 August 2018, it was announced that Kate Oates, who has previously been a producer on the ITV soap operas Emmerdale and Coronation Street, would become Senior Executive Producer of EastEnders, as well of Holby City and Casualty. Oates began her role in October, and continued to work with Yorke until the end of the year to "ensure a smooth handover".[94] It was also announced that Oates was looking for an Executive Producer to work under her.[95] Jon Sen was announced on 10 December 2018 to be taking on the role of executive producer.[96]

In late 2016, popularity and viewership of EastEnders began to decline, with viewers criticising the storylines during the O'Connor reign, such as the killing of the Mitchell sisters and a storyline centred around the local bin collection.[97] Although, since Yorke and Oates' reigns, opinions towards the storylines have become more favourable, with storylines such as Ruby Allen’s (Louisa Lytton) sexual consent, which featured a special episode which "broke new ground"[98] and knife crime, both of which have created "vital" discussions. The soap won the award for Best Continuing Drama at the 2019 British Academy Television Awards; its first high-profile award since 2016. However, in June 2019, EastEnders suffered its lowest ever ratings of 2.4 million due to its airing at 7pm because of the BBC's coverage of the 2019 FIFA Women's World Cup.[99] As of 2019, the soap is one of the most watched series on BBC iPlayer and averages around 5 million viewers per episode.[100][101] The soap enjoyed a record-breaking year on the streaming platform in 2019, with viewers requesting to stream or download the show 234 million times, up 10% on 2018.[citation needed] The Christmas Day episode in 2019 became EastEnders biggest ever episode on BBC iPlayer, with 2.14 million viewer requests.

2020s
In February 2020, EastEnders celebrated its 35th anniversary with a stunt on the River Thames leading to the death of Dennis Rickman Jnr (Bleu Landau).[102][103] On 18 March 2020, it was announced that filming for EastEnders would be suspended "In light of the spread of COVID-19" and that the number of episodes being broadcast would be reduced to two a week "so that we can ensure the audience can continue to enjoy EastEnders in their homes for as long as possible." The episodes would be shown on Mondays and Tuesdays in the usual time slot.[104]

Setting
The central focus of EastEnders is the fictional Victorian square Albert Square in the fictional London Borough of Walford. In the show's narrative, Albert Square is a 19th-century street, named after Prince Albert (1819–1861), the husband of Queen Victoria (1819–1901, reigned 1837–1901). Thus, central to Albert Square is The Queen Victoria Public House (also known as The Queen Vic or The Vic).[105] The show's producers based the square's design on Fassett Square in Dalston.[106] There is also a market close to Fassett Square at Ridley Road. The postcode for the area, E8, was one of the working titles for the series.[17] The name Walford is both a street in Dalston where Tony Holland lived and a blend of Walthamstow and Stratford—the areas of Greater London where the creators were born.[17][107] Other parts of the Square and set interiors are based on other locations. The bridge is based upon one near BBC Television Centre which carries the Hammersmith & City tube line over Wood Lane W12, the Queen Vic on the former College Park Hotel pub in Willesden at the end of Scrubs Lane at the junction with Harrow Road NW10 just a couple of miles from BBC Television Centre,[108] and the interior to the Fowlers' is based on a house in Manor Road, Colchester, close to where the supervising art director lived.[citation needed] The fictional local newspaper, the Walford Gazette, in which local news events such as the arrests or murders of characters appear, mirrors the real Hackney Gazette.[citation needed]

Walford East is a fictional tube station for Walford, and a tube map that was first seen on air in 1996 showed Walford East between Bow Road and West Ham, in the actual location of Bromley-by-Bow on the District and Hammersmith & City lines.[109]

Walford has the postal district of E20. It was named as if Walford were part of the actual E postcode area which covers much of east London,[110] the E standing for Eastern.[111] E20 was entirely fictional when it was created, as London East postal districts stopped at E18 at the time. The show's creators opted for E20 instead of E19 as it was thought to sound better.[107] The numbering system in real life comes from the alphabetised names of the main sorting office for each district.[112] If part of this real-life classification, Walford would have been assigned E17, which is the actual postcode district for Walthamstow.

In March 2011, Royal Mail allocated the E20 postal district to the 2012 Olympic Park.[113] In September 2011, the postcode for Albert Square was revealed in an episode as E20 6PQ.

Characters
EastEnders is built around the idea of relationships and strong families, with each character having a place in the community. This theme encompasses the whole Square, making the entire community a family of sorts, prey to upsets and conflict, but pulling together in times of trouble. Co-creator Tony Holland was from a large East End family, and such families have typified EastEnders.[20] The first central family was the combination of the Fowler family, consisting of Pauline Fowler (Wendy Richard), her husband Arthur (Bill Treacher), and teenage children Mark (David Scarboro/Todd Carty) and Michelle (Susan Tully). Pauline's family, the Beales, consisted of Pauline's twin brother Pete Beale (Peter Dean), his wife Kathy (Gillian Taylforth) and their teenage son Ian (Adam Woodyatt). Pauline and Pete's domineering mother Lou Beale (Anna Wing) lived with Pauline and her family. Holland drew on the names of his own family for the characters.[21]

The Watts and Mitchell families have been central to many notable EastEnders storylines, the show having been dominated by the Watts in the 1980s, with the 1990s focusing on the Mitchells. The early 2000s saw a shift in attention towards the newly introduced female Slater clan, before a renewal of emphasis upon the restored Watts family beginning in 2003. Since 2006, EastEnders has largely been dominated by the Mitchell, Ahmed and Branning families, though the early 2010s also saw a renewed focus on the Moon family, and from 2013 onwards, on the Carters. In 2014, the Fowlers were revived and merged with the Slaters, with Martin Fowler (James Bye) marrying Stacey Slater (Lacey Turner). The Taylor family were introduced in 2017 and have been central to the show's main storylines. Key people involved in the production of EastEnders have stressed how important the idea of strong families is to the programme.[20]

EastEnders has an emphasis on strong family matriarchs, with examples including Pauline Fowler (Wendy Richard) and Peggy Mitchell (Barbara Windsor), helping to attract a female audience. John Yorke, then the BBC's head of drama production, put this down to Tony Holland's "gay sensibility, which showed a love for strong women".[114] The matriarchal role is one that has been seen in various reincarnations since the programme's inception, often depicted as the centre of the family unit.[115] The original matriarch was Lou Beale (Anna Wing), though later examples include Mo Harris (Laila Morse),[116] Pat Butcher (Pam St Clement),[117] Zainab Masood (Nina Wadia),[118] Cora Cross (Ann Mitchell),[119] Kathy Beale (Gillian Taylforth),[120] Jean Slater (Gillian Wright),[121] and Suki Panesar (Balvinder Sopal).[122] These characters are often seen as being loud and interfering but most importantly, responsible for the well-being of the family[123] and usually stressing the importance of family.

The show often includes strong, brassy, long-suffering women who exhibit diva-like behaviour and stoically battle through an array of tragedy and misfortune.[123] Such characters include Angie Watts (Anita Dobson), Kathy Beale (Gillian Taylforth), Sharon Watts (Letitia Dean), Pat Butcher (Pam St Clement), Kat Slater (Jessie Wallace), Denise Fox (Diane Parish), Tanya Branning (Jo Joyner) and Linda Carter (Kellie Bright). Conversely there are female characters who handle tragedy less well, depicted as eternal victims and endless sufferers, who include Ronnie Mitchell (Samantha Womack), Little Mo Slater (Kacey Ainsworth), Laura Beale (Hannah Waterman), Sue Osman (Sandy Ratcliff), Lisa Fowler (Lucy Benjamin) and Mel Owen (Tamzin Outhwaite). The 'tart with a heart' is another recurring character, often popular with viewers. Often their promiscuity masks a hidden vulnerability and a desire to be loved. Such characters have included Pat Butcher (Pam St Clement) (though in her latter years, this changed), Tiffany Mitchell (Martine McCutcheon), Kat Slater (Jessie Wallace),[124] Stacey Slater (Lacey Turner), Dawn Swann (Kara Tointon), Roxy Mitchell (Rita Simons), Whitney Dean (Shona McGarty) and Lauren Branning (Jacqueline Jossa).

A gender balance in the show is maintained via the inclusion of various "macho" male personalities such as Mick Carter (Danny Dyer), Phil Mitchell (Steve McFadden), Grant Mitchell (Ross Kemp), Dennis Rickman (Nigel Harman), Jack Branning (Scott Maslen) and Max Branning (Jake Wood), "bad boys" such as Den Watts (Leslie Grantham), Sean Slater (Robert Kazinsky), Michael Moon (Steve John Shepherd) and Vincent Hubbard (Richard Blackwood), and "heartthrobs" such as Simon Wicks (Nick Berry), Jamie Mitchell (Jack Ryder), Dennis Rickman (Nigel Harman), Joey Branning (David Witts), Kush Kazemi (Davood Ghadami) and Keanu Taylor (Danny Walters). Another recurring male character type is the smartly dressed businessman, often involved in gang culture and crime and seen as a local authority figure. Examples include Steve Owen (Martin Kemp), Jack Dalton (Hywel Bennett), Andy Hunter (Michael Higgs),[125] Johnny Allen (Billy Murray) and Derek Branning (Jamie Foreman). Following criticism aimed at the show's over-emphasis on "gangsters" in 2005, such characters have been significantly reduced.[125] Another recurring male character seen in EastEnders is the 'loser' or 'soft touch', males often comically under the thumb of their female counterparts, which have included Arthur Fowler (Bill Treacher),[123] Ricky Butcher (Sid Owen), Garry Hobbs (Ricky Groves), Lofty Holloway (Tom Watt) and Billy Mitchell (Perry Fenwick).[126] Other recurring character types that have appeared throughout the serial are "cheeky-chappies" Pete Beale (Peter Dean), Alfie Moon (Shane Richie), Garry Hobbs (Ricky Groves) and Kush Kazemi (Davood Ghadami), "lost girls" such as Mary Smith (Linda Davidson), Donna Ludlow (Matilda Ziegler), Mandy Salter (Nicola Stapleton) and Hayley Slater (Katie Jarvis), delinquents such as Stacey Slater (Lacey Turner), Jay Brown (Jamie Borthwick), Lola Pearce (Danielle Harold), Bobby Beale (Eliot Carrington/Clay Milner Russell) and Keegan Baker (Zack Morris), "villains" such as Nick Cotton (John Altman), Trevor Morgan (Alex Ferns), May Wright (Amanda Drew), Yusef Khan (Ace Bhatti), Archie Mitchell (Larry Lamb), Dean Wicks (Matt Di Angelo) and Stuart Highway (Ricky Champ), "bitches" such as Cindy Beale (Michelle Collins), Janine Butcher (Charlie Brooks), Sam Mitchell (Danniella Westbrook),[127] Lucy Beale (Melissa Suffield/Hetti Bywater), Abi Branning (Lorna Fitzgerald), Babe Smith (Annette Badland) and Louise Mitchell (Tilly Keeper), "brawlers" or "fighters" such as Bianca Jackson (Patsy Palmer), Kat Slater (Jessie Wallace), Chelsea Fox (Tiana Benjamin), Dawn Swann (Kara Tointon), Stacey Slater (Lacey Turner) and Karen Taylor (Lorraine Stanley), and cockney "wide boys" or "wheeler dealers"[12] such as Frank Butcher (Mike Reid), Alfie Moon (Shane Richie), Kevin Wicks (Phil Daniels), Darren Miller (Charlie G. Hawkins), Fatboy (Ricky Norwood) and Jay Brown (Jamie Borthwick).

Over the years EastEnders has typically featured a number of elderly residents, who are used to show vulnerability, nostalgia, stalwart-like attributes and are sometimes used for comedic purposes. The original elderly residents included Lou Beale (Anna Wing), Ethel Skinner (Gretchen Franklin) and Dot Cotton (June Brown). Over the years they have been joined by the likes of Mo Butcher (Edna Doré), Jules Tavernier (Tommy Eytle), Marge Green (Pat Coombs), Nellie Ellis (Elizabeth Kelly), Jim Branning (John Bardon), Charlie Slater (Derek Martin), Mo Harris (Laila Morse), Patrick Trueman (Rudolph Walker), Cora Cross (Ann Mitchell), Les Coker (Roger Sloman), Rose Cotton (Polly Perkins), Pam Coker (Lin Blakley), Stan Carter (Timothy West), Babe Smith (Annette Badland), Claudette Hubbard (Ellen Thomas), Sylvie Carter (Linda Marlowe), Ted Murray (Christopher Timothy), Joyce Murray (Maggie Steed), Arshad Ahmed (Madhav Sharma) and Mariam Ahmed (Indira Joshi). The programme has more recently included a higher number of teenagers and successful young adults in a bid to capture the younger television audience.[128][129] This has spurred criticism, most notably from the actress Anna Wing, who portrayed Lou Beale in the show. She commented, "I don't want to be disloyal, but I think you need a few mature people in a soap because they give it backbone and body... if all the main people are young it gets a bit thin and inexperienced. It gets too lightweight."[130]

EastEnders has been known to feature a 'comedy double-act', originally demonstrated with the characters of Dot and Ethel, whose friendship was one of the serial's most enduring.[131] Other examples include Paul Priestly (Mark Thrippleton) and Trevor Short (Phil McDermott),[132] In 1989 especially, characters were brought in who were deliberately conceived as comic or light-hearted.[33] Such characters included Julie Cooper (Louise Plowright)—a brassy maneater; Marge Green—a batty older lady played by veteran comedy actress Pat Coombs; Trevor Short (Phil McDermott)—the "village idiot"; his friend, northern heartbreaker Paul Priestly (Mark Thrippleton); wheeler-dealer Vince Johnson (Hepburn Graham) and Laurie Bates (Gary Powell), who became Pete Beale's (Peter Dean) sparring partner.[36] The majority of EastEnders' characters are working-class.[133] Middle-class characters do occasionally become regulars, but have been less successful and rarely become long-term characters. In the main, middle-class characters exist as villains, such as James Wilmott-Brown (William Boyde), May Wright (Amanda Drew), Stella Crawford (Sophie Thompson) and Yusef Khan (Ace Bhatti) or are used to promote positive liberal influences, such as Colin Russell (Michael Cashman) or Rachel Kominski (Jacquetta May).[123]

EastEnders has always featured a culturally diverse cast which has included black, Asian, Turkish, Polish and Latvian characters. "The expansion of minority representation signals a move away from the traditional soap opera format, providing more opportunities for audience identification with the characters and hence a wider appeal".[134][135] Despite this, the programme has been criticised by the Commission for Racial Equality, who argued in 2002 that EastEnders was not giving a realistic representation of the East End's "ethnic make-up". They suggested that the average proportion of visible minority faces on EastEnders was substantially lower than the actual ethnic minority population in East London boroughs, and it therefore reflected the East End in the 1960s, not the East End of the 2000s. The programme has since attempted to address these issues. A sari shop was opened and various characters of different ethnicities were introduced throughout 2006 and 2007, including the Fox family, the Ahmeds, and various background artists.[136] This was part of producer Diederick Santer's plan to "diversify", to make EastEnders "feel more 21st century". EastEnders has had varying success with ethnic minority characters. Possibly the least successful were the Indian Ferreira family, who were not well received by critics or viewers and were dismissed as unrealistic by the Asian community in the UK.[137]

EastEnders has been praised for its portrayal of characters with disabilities, including Adam Best (David Proud) (spina bifida), Noah Chambers (Micah Thomas) (deaf), Jean Slater (Gillian Wright) and her daughter Stacey (Lacey Turner) (bipolar disorder), Janet Mitchell (Grace) (Down syndrome), Jim Branning (John Bardon) (stroke) [138] and Dinah Wilson (Anjela Lauren Smith) (multiple sclerosis). The show also features a large number of gay, lesbian and bisexual characters (see list of soap operas with LGBT characters), including Colin Russell (Michael Cashman), Barry Clark (Gary Hailes),[139] Simon Raymond (Andrew Lynford), Tony Hills (Mark Homer),[140] Sonia Fowler (Natalie Cassidy), Naomi Julien (Petra Letang),[141] Tina Carter (Luisa Bradshaw-White), Tosh Mackintosh (Rebecca Scroggs),[142] Ben Mitchell (Harry Reid/Max Bowden), Paul Coker (Jonny Labey),[143] Iqra Ahmed (Priya Davdra), and Ash Kaur (Gurlaine Kaur Garcha). Kyle Slater (Riley Carter Millington), a transgender character, was introduced in 2015.[144]

EastEnders has a high cast turnover and characters are regularly changed to facilitate storylines or refresh the format.[145] The show has also become known for the return of characters after they have left the show. Sharon Watts (Letitia Dean) returned in August 2012 for her third stint on the show. Den Watts (Leslie Grantham) returned 14 years after he was believed to have died, a feat repeated by Kathy Beale (Gillian Taylforth) in 2015.[146] Speaking extras, including Tracey the barmaid (Jane Slaughter) (who has been in the show since the first episode in 1985), have made appearances throughout the show's duration, without being the focus of any major storylines. The character of Nick Cotton (John Altman) gained a reputation for making constant exits and returns since the programme's first year, until the character's death in 2015.[147]

As of October 2019, Adam Woodyatt, Gillian Taylforth and Letitia Dean are the only members of the original cast remaining in the show, in their roles of Ian Beale, Kathy Beale and Sharon Watts respectively. Ian Beale is the only character to have appeared continuously from the first episode without formally leaving, and is the longest-serving character in EastEnders. [148] Dot Cotton and Tracey are the longest-serving female character in the show having served since 1985

Motor neurone disease

Motor neurone disease

Motor neuron diseases (MNDs) are a group of rare neurodegenerative disorders that selectively affect motor neurons, the cells which control voluntary muscles of the body.[2][3]

According to ICD-11, the following disorders are counted among motor neuron diseases: amyotrophic lateral sclerosis (ALS), progressive bulbar palsy (PBP), pseudobulbar palsy, progressive muscular atrophy (PMA), primary lateral sclerosis (PLS), and monomelic amyotrophy (MMA), as well as some rarer variants resembling ALS.

Motor neuron diseases affect both children and adults.[4] While each motor neuron disease affects patients differently, they all cause movement-related symptoms, mainly muscle weakness.[5] Most of these diseases seem to occur randomly without known causes, but some forms are inherited.[3] Studies into these inherited forms have led to discoveries of various genes (e.g. SOD1) that are thought be important in understanding how the disease occurs.[6]

Symptoms of motor neuron diseases can be first seen at birth or can come on slowly later in life. Most of these diseases worsen over time; while some of them shorten one's life expectancy (e.g. ALS), others do not.[3]

Currently, there are no approved treatments for the majority of motor neuron disorders, and care is mostly symptomatic.
igns and symptoms depend on the specific disease, but motor neuron diseases typically manifest as a group of movement-related symptoms.[5] They come on slowly, and worsen over the course of more than three months. Various patterns of muscle weakness are seen, and muscle cramps and spasms may occur. One can have difficulty breathing with climbing stairs (exertion), difficulty breathing when lying down (orthopnea), or even respiratory failure if breathing muscles become involved. Bulbar symptoms, including difficulty speaking (dysarthria), difficulty swallowing (dysphagia), and excessive saliva production (sialorrhea), can also occur. Sensation, or the ability to feel, is typically not affected. Emotional disturbance (e.g. pseudobulbar affect) and cognitive and behavioural changes (e.g. problems in word fluency, decision-making, and memory) are also seen.[3][5] There can be lower motor neuron findings (e.g. muscle wasting, muscle twitching), upper motor neuron findings (e.g. brisk reflexes, Babinski reflex, Hoffman's reflex, increased muscle tone), or both.[5]

Motor neuron diseases are seen both in children and in adults.[3] Those that affect children tend to be inherited or familial, and their symptoms are either present at birth or appear before learning to walk. Those that affect adults tend to appear after age 40.[3] The clinical course depends on the specific disease, but most progress or worsen over the course of months.[5] Some are fatal (e.g. ALS), while others are not (e.g. PLS).[3]

Patterns of weakness
Various patterns of muscle weakness occur in different motor neuron diseases.[5] Weakness can be symmetric or asymmetric, and it can occur in body parts that are distal, proximal, or both... According to Statland et al., there are three main weakness patterns that are seen in motor neuron diseases, which are:[5][8]

Asymmetric distal weakness without sensory loss (e.g. ALS, PLS, PMA, MMA)
Symmetric weakness without sensory loss (e.g. PMA, PLS)
Symmetric focal midline proximal weakness (neck, trunk, bulbar involvement; e.g. ALS, PBP, PLS)
Lower and upper motor neuron findings
Motor neuron diseases are on a spectrum in terms of upper and lower motor neuron involvement.[5] Some have just lower or upper motor neuron findings, while others have a mix of both. Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal reflexes.[3][5]

Pure upper motor neuron diseases, or those with just UMN findings, include PLS.

Pure lower motor neuron diseases, or those with just LMN findings, include PMA.

Motor neuron diseases with both UMN and LMN findings include both familial and sporadic ALS.

Causes
Most cases are sporadic and their causes are usually not known.[3] It is thought that environmental, toxic, viral, or genetic factors may be involved.[3]

DNA damage
TARDBP (TAR DNA-binding protein 43), also referred to as TDP-43, is a critical component of the non-homologous end joining (NHEJ) enzymatic pathway that repairs DNA double-strand breaks in pluripotent stem cell-derived motor neurons.[9] TDP-43 is rapidly recruited to double-strand breaks where it acts as a scaffold for the recruitment of the XRCC4-DNA ligase protein complex that then acts to repair double-strand breaks. About 95% of ALS patients have abnormalities in the nucleus-cytoplasmic localization in spinal motor neurons of TDP43. In TDP-43 depleted human neural stem cell-derived motor neurons, as well as in sporadic ALS patients’ spinal cord specimens there is significant double-strand break accumulation and reduced levels of NHEJ.[9]

Associated risk factors
In adults, men are more commonly affected than women.[3]

Diagnosis
Differential diagnosis can be challenging due to the number of overlapping symptoms, shared between several motor neuron diseases. Frequently, the diagnosis is based on clinical findings (i.e. LMN vs. UMN signs and symptoms, patterns of weakness), family history of MND, and a variation of tests, many of which are used to rule out disease mimics, which can manifest with identical symptoms.

Please refer to individual articles for the diagnostic methods used in each individual motor neuron disease.

Classification
Motor neuron disease describes a collection of clinical disorders, characterized by progressive muscle weakness and the degeneration of the motor neuron on electrophysiological testing. As discussed above, the term "motor neuron disease" has varying meanings in different countries. Similarly, the literature inconsistently classifies which degenerative motor neuron disorders can be included under the umbrella term "motor neuron disease". The four main types of MND are marked (*) in the table below.[10]

All types of MND can be differentiated by two defining characteristics:[5]

Is the disease sporadic or inherited?
Is there involvement of the upper motor neurons (UMN), the lower motor neurons (LMN), or both?
Sporadic or acquired MNDs occur in patients with no family history of degenerative motor neuron disease. Inherited or genetic MNDs adhere to one of the following inheritance patterns: autosomal dominant, autosomal recessive, or X-linked. Some disorders, like ALS, can occur sporadically (85%) or can have a genetic cause (15%) with the same clinical symptoms and progression of disease.[5]

UMNs are motor neurons that project from the cortex down to the brainstem or spinal cord.[11] LMNs originate in the anterior horns of the spinal cord and synapse on peripheral muscles.[11] Both motor neurons are necessary for the strong contraction of a muscle, but damage to an UMN can be distinguished from damage to a LMN by physical exam.
Tests
Cerebrospinal fluid (CSF) tests: Analysis of the fluid from around the brain and spinal cord could reveal signs of an infection or inflammation.[12]
Magnetic resonance imaging (MRI): An MRI of the brain and spinal cord is recommended in patients with UMN signs and symptoms to explore other causes, such as a tumor, inflammation, or lack of blood supply (stroke).[12]
Electromyogram (EMG) & nerve conduction study (NCS): The EMG, which evaluates muscle function, and NCS, which evaluates nerve function, are performed together in patients with LMN signs.
For patients with MND affecting the LMNs, the EMG will show evidence of: (1) acute denervation, which is ongoing as motor neurons degenerate, and (2) chronic denervation and reinnervation of the muscle, as the remaining motor neurons attempt to fill in for lost motor neurons.[12]
By contrast, the NCS in these patients is usually normal. It can show a low compound muscle action potential (CMAP), which results from the loss of motor neurons, but the sensory neurons should remain unaffected.[13]
Tissue biopsy: Taking a small sample of a muscle or nerve may be necessary if the EMG/NCS is not specific enough to rule out other causes of progressive muscle weakness, but it is rarely used.
Treatment
There are no known curative treatments for the majority of motor neuron disorders. Please refer to the articles on individual disorders for more details.

سانوفي

سانوفي

وهي شركة فرنسية ذات مناشئ عالمية مختلفة مقرها في باريس، فرنسا، احتلت عام 2013 المركز الخامس بين أكبر الشركات مبيعاً للوصفات الطبية، أنشئت الشركة تحت اسم سانوفي أفينتس عام 2004 بعد دمج شركتي أفينتس وسانوفي-سينتيلابو، اللتان انشئتا بالأصل بعد دمج عدة شركات اخرى مسبقاَ,وثم غيرت اسمها إلى سانوفي في مارس 2011

تعمل سانوفي في البحث والتطوير، صناعة وتسويق الأدوية، بالأخص في سوق الوصفات الطبية، لكن المؤسسة طورت أدوية متاحة بدون وصفة، وتغطي الشركة سبعة مجالات علاجية رئيسية وهي : الأمراض القلبية الوعائية، الجهاز العصبي المركزي، مرض السكري، الطب الداخلي (الباطني)، علم الأورام، تخثر الدم واللقاحات (وهي أكبر منتجة للأخير في العالم خلال فرعها سانوفي باستور).
المنتجات
الأدوية والوصفات الطبية
المناعة الذاتية
قلم إيبنفرين  حساسية.
تيريفلونوميد لمرض التصلب المتعدد. وافقت عليها إدارة الاغذية والعقاقير في سبتمبر 2012.
القلب والأوعية الدموية
كلوبيدوغريل (Plavix, Iscover) (بلافيكس ، إيسكوفر) لتصلب الشرايين
إينوكسابارين (Lovenox, Clexane) للتخثر (أكبر بائع لها في عام 2008)
Mipomersen (Kynamro)، علاج عكسي لاتجاه النسخ وهو دواء مضاد للتجلط اخترعته شركة إيزيس للأدوية ، وحصلت عليه جنزيم في عام 2008 (ما قبل سانوفي) وتمت الموافقة عليه من قبل إدارة الأغذية والعقاقير في عام 2013 لمرض فرط كوليستيرول الدم العائلي مرض نادر.
إربيسارتان (Aprovel, Avapro, Karvea) و راميبريل (Delix, Triatec, Tritace) لارتفاع ضغط الدم
أليروكوماب (Praluent) لفرط كوليستيرول الدم العائلي غير المتماثل وأمراض القلب والأوعية الدموية تصلب الشرايين السريرية
دوبيلوماب (Dupixent) لمرض التأتبي
الأمراض المعدية
مضادات حيوية:
سيفوتاكسيم (Claforan) كلافوران
ريفابنتين (Priftin) بريفتين
ليفوفلوكساسين (Tavanic) تافانيك
أموكسيسيلين/حمض الكلافولانيك (Amoklavin) أموكلافين
اللقاحات:
الأمراض البكتيرية:
كوليرا
خناق
مستدمية نزلية
لقاح المكورات السحائية (Menactra)
سعال ديكي
لقاح المكورة الرئوية
كزاز
سل
حمى التيفوئيد
الأمراض الفيروسية:
التهاب الكبد الوبائي أ
التهاب الكبد ب
إنفلونزا
التهاب الدماغ الياباني (Ixiaro) اكسيارو
حصبة
نكاف
شلل الأطفال
داء الكلب
حصبة ألمانية
جدري الماء
حمى صفراء
جدري - تم استئصاله في عام 1980 (تم إنتاج اللقاح كتدبير استجابة لتهديد الإرهاب البيولوجي)
الأيض
غليمبريد (Amaryl) لمرضى السكري من النوع 2
إنسولين (Insuman) للنوع 1 والنوع الثاني من مرض السكري
أنسولين غلوليزين (Apidra) and إنسولين غلارجين (Lantus) for السكري
Risedronic acid (Actonel) لمرض هشاشة العظام هشاشة العظام و مرض بادجيت
سيفيلامير hydrochloride (Renagel and Renvela) مرض الكلى المزمن
carmustine implants (Gliadel) للسرطان
الأعصاب
Sodium hyaluronate (Hyalgan) for تحليل الدم
حمض الفالبرويك (Depakine) و حمض الفالبرويك (Depakote) لعلاج صرع
زولبيديم (Ambien, Ambien CR, Myslee, Stilnoct, Stilnox, Zolfresh, Zolt) for أرق
أليمتوزوماب (Lemtrada) لمرض التصلب المتعدد
تيريفلونوميد (Aubagio) لمرض التصلب المتعدد
الأورام
• Cabazitaxel (Jevtana) • Plerixafor ( Mozobil ) ، macrocycle [85] • Aflibercept (ZALTRAP) بروتين الاندماج المؤتلف ، [28]

ألفوزوسين (Xatral/Uroxatral) لتضخم البروستاتا الحميد
Cabazitaxel (Jevtana) لسرطان البروستاتا
بليريكسافور   (Mozobil), حلقة ضخمةالتي وافقت عليها إدارة الغذاء والدواء لتعبئة الخلايا الجذعية في الدم المحيطي ليمفوما اللاهودجكينز والورم النخاعي المتعدد في ديسمبر 2008 
أفليبيرسيبت (ZALTRAP) حمض نووي معاد التركيب بروتين اندماجي, approved in metastatic colorectal cancer المعتمد في سرطان القولون والمستقيم المنتشر بالاشتراك مع عوامل أخرى في عام 2012..
كلوميفين (Clomid)لعلاج العقم عند المرأة
دوسيتاكسيل (Taxotere) لسرطان الثدي, سرطان الرئة و سرطان البروستاتا
أوكساليبلاتين (Eloxatin) ل لسرطان القولون
Sarilumab (Kevzara) لاختبارات الدم وسرطان الرئة وسرطان البروستاتا
Vandetanib (Caprelsa) لسرطان الثدي وسرطان القولون والمستقيم والعقم عند النساء
الألم
كودين (Solpadol) للألم المزمن
كيتوبروفين (Bi-profined) للألم
مرض السكري
إنسولين غلارجين (insulin glargine) للنوع 1 والنوع 2 من داء السكري
إنسولين غلارجين (insulin glargine) للنوع 1 والنوع 2 من داء السكري
أنسولين غلوليزين (insulin glulisin) للنوع 1 والنوع 2 من داء السكري
دون وصفة طبية
فيكسوفينادين (Allegra, Telfast) وتريامسينولون (Nasacort) لحساسية الأنف
باراسيتامول (Novaldol)
كربونات الكالسيوم (Maalox, مضاد الحموضة)
تنتج الشركة أيضًا مجموعة واسعة من المنتجات التي لا تحتاج إلى وصفة طبية ، من بينها فيكسوفينادين ومروخ لألم العضلات و Gold Bond لتهيج الجلد وشامبو Selsun Blue dandruff. تم الحصول على هذه العلامات التجارية في عام 2010 عندما اشترت سانوفي-أفنتيس شركة Chattem.

Plaquenil

Plaquenil

 sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria.[1] Specifically it is used for chloroquine-sensitive malaria.[2] Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.[1] It is taken by mouth.[1]

Common side effects include vomiting, headache, changes in vision and muscle weakness.[1] Severe side effects may include allergic reactions.[1] It does not appear to be safe during pregnancy.[3] Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication.[1]

Hydroxychloroquine was approved for medical use in the United States in 1955.[1] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[4] The wholesale cost in the developing world is about $4.65 per month as of 2015 when used for rheumatoid arthritis or lupus.[5] In the United States the wholesale cost of a month of treatment is about US$25 as of 2019.[6] In the United Kingdom this dose costs the NHS about £5.15.[7] In 2016 it was the 135th most prescribed medication in the United States with more than 4 million prescriptions
Medical use
Hydroxychloroquine treats malaria, systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever.[1]

In 2014, its efficacy to treat Sjögren syndrome was questioned in a double-blind study involving 120 patients over a 48-week period.[9]

Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis.[10]

On March 17 the Italian Pharmaceutical Agency has included hydroxychloroquine in the list of drugs with positive preliminary results for treatment of coronavirus disease 2019.[11] In vitro studies have demonstrated that hydroxychloroquine is more potent than chloroquine against SARS-CoV-2 with a more tolerable safety profile.[12]

Adverse effects
The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. The most serious adverse effects affect the eye.

For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting.

For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. Hydroxychloroquine can worsen existing cases of both psoriasis and porphyria.

Eyes
One of the most serious side effects is a toxicity in the eye (generally with chronic use).[13] People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. The daily safe maximum dose for eye toxicity can be computed from one's height and weight using this calculator. Cumulative doses can also be calculated from this calculator. Macular toxicity is related to the total cumulative dose rather than the daily dose. Regular eye screening, even in the absence of visual symptoms, is recommended to begin when either of these risk factors occurs.[14]

Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye: the cornea and the macula. The cornea may become affected (relatively commonly) by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine.

The macular changes are potentially serious. Advanced retinopathy is characterized by reduction of visual acuity and a "bull's eye" macular lesion which is absent in early involvement.

Interactions
The drug transfers into breast milk and should be used with care by pregnant or nursing mothers.[citation needed]

Hydroxychloroquine generally does not have significant interactions with other medications, but care should be taken if combined with medication altering liver function as well as aurothioglucose (Solganal), cimetidine (Tagamet) or digoxin (Lanoxin). HCQ can increase plasma concentrations of penicillamine which may contribute to the development of severe side effects. It enhances hypoglycemic effects of insulin and oral hypoglycemic agents. Dose altering is recommended to prevent profound hypoglycemia. Antacids may decrease the absorption of HCQ. Both neostigmine and pyridostigmine antagonize the action of hydroxychloroquine.[15]

While there may be a link between hydroxychloroquine and hemolytic anemia in those with glucose-6-phosphate dehydrogenase deficiency, this risk may be low in those of African descent.[16]

Overdose
Due to rapid absorption, symptoms of overdose can occur within a half an hour after ingestion. Overdose symptoms include convulsions, drowsiness, headache, heart problems or heart failure, difficulty breathing and vision problems.

Pharmacology
Pharmacokinetics
Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption and elimination by the kidneys. Cytochrome P450 enzymes (CYP2D6, 2C8, 3A4 and 3A5) metabolize hydroxychloroquine to N-desethylhydroxychloroquine.[17]

Pharmacodynamics
Antimalarials are lipophilic weak bases and easily pass plasma membranes. The free base form accumulates in lysosomes (acidic cytoplasmic vesicles) and is then protonated,[18] resulting in concentrations within lysosomes up to 1000 times higher than in culture media. This increases the pH of the lysosome from 4 to 6.[19] Alteration in pH causes inhibition of lysosomal acidic proteases causing a diminished proteolysis effect.[20] Higher pH within lysosomes causes decreased intracellular processing, glycosylation and secretion of proteins with many immunologic and nonimmunologic consequences.[21] These effects are believed to be the cause of a decreased immune cell functioning such as chemotaxis, phagocytosis and superoxide production by neutrophils.[22] HCQ is a weak diprotic base that can pass through the lipid cell membrane and preferentially concentrate in acidic cytoplasmic vesicles. The higher pH of these vesicles in macrophages or other antigen-presenting cells limits the association of autoantigenic (any) peptides with class II MHC molecules in the compartment for peptide loading and/or the subsequent processing and transport of the peptide-MHC complex to the cell membrane.[23]

Mechanism of action
Hydroxychloroquine increases[24] lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells (PDCs).[citation needed] Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process. Toll-like receptor 9 (TLR 9) recognizes DNA-containing immune complexes and leads to the production of interferon and causes the dendritic cells to mature and present antigen to T cells, therefore reducing anti-DNA auto-inflammatory process.

In 2003, a novel mechanism was described wherein hydroxychloroquine inhibits stimulation of the toll-like receptor (TLR) 9 family receptors. TLRs are cellular receptors for microbial products that induce inflammatory responses through activation of the innate immune system.[25]

As with other quinoline antimalarial drugs, the mechanism of action of quinine has not been fully resolved. The most accepted model is based on hydrochloroquinine and involves the inhibition of hemozoin biocrystallization, which facilitates the aggregation of cytotoxic heme. Free cytotoxic heme accumulates in the parasites, causing their deaths.[citation needed]

Brand names
It is frequently sold as a sulfate salt known as hydroxychloroquine sulfate.[1] 200 mg of the sulfate salt is equal to 155 mg of the base.[26]

Brand names of hydroxychloroquine include Plaquenil, Hydroquin, Axemal (in India), Dolquine, Quensyl, Quinoric.[

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