السبت، 11 أبريل 2020

Uddhav Thackeray

Uddhav Thackeray

Uddhav Bal Thackeray (born 27 July 1960) is an Indian politician serving as the 19th and current Chief Minister of Maharashtra.[2][3][4] He is the president of Shiv Sena.
Early life and education
Uddhav Thackeray was born on 27 July 1960 as the youngest of politician Bal Thackeray and his wife Meena Thackeray's three sons.[2][5] He did his schooling in Balmohan Vidyamandir and graduated from Sir J.J. Institute of Applied Art.[6]

Early political career
In 2002, Thackeray started his political career as campaign incharge of Shiv Sena in the Brihan Mumbai Municipal Corporation elections where the party performed well. In 2003, he was appointed as working president of Shiv Sena. Uddhav took over as chief editor of party mouthpiece Saamana (a daily Marathi-language newspaper published by Shiv Sena) in 2006 and resigned in 2019 before becoming chief minister of Maharashtra.[7]

A split in Shiv Sena happened when his cousin Raj Thackeray left the party in 2006 to form his own party named Maharashtra Navnirman Sena.[8] After the death of his father Bal Thackeray in 2012, he led the party and got elected as Shiv Sena president in 2013, and under his leadership Shiv Sena joined the NDA government in Maharashtra in 2014.[9]

Chief Minister of Maharashtra
Though Thackeray never took any constitutional post in his political career initially, however after a brief political crisis, on 28 November 2019 he took the oath as 19th Chief minister of Maharashtra after being elected as leader of the newly formed post-poll coalition Maha Vikas Aghadi.[10][3][4]

Personal life
Thackeray is married to Rashmi Thackeray and has two sons, Aditya and Tejas.[11]

While elder son Aditya is the president of the Yuva Sena, younger son Tejas is believed to be studying in a college in Buffalo, New York. Tejas has maintained a very low profile unlike his father and elder brother. On 16 July 2012, Uddhav Thackeray was admitted to Lilavati Hospital after he reported chest pain. He underwent an angioplasty and all the three blockages in his arteries were successfully removed.[12]

Thackeray is keen in photography and has exhibited his collection of aerial shots of various forts of Maharashtra at the Jehangir Art Gallery in 2004.[13][14] He has also published photo-books Maharashtra Desh (2010) and Pahava Vitthal (2011), capturing various aspects of Maharashtra and the warkaris during Pandharpur Wari respectively in the two books

Mahatma Phule

Mahatma Phule

Mahatma Jyotirao Govindrao Phule[a] (11 April 1827 – 28 November 1890), also known as Jyotiba Phule, was an Indian social activist, thinker, anti-caste social reformer and writer from Maharashtra. His work extended to many fields including eradication of untouchability and the caste system, and women's emancipation.He is mostly known for his efforts in educating women and lower caste people. He and his wife, Savitribai Phule, were pioneers of women education in India. Phule started his first school for girls in 1848 in Pune at Tatyasaheb Bhide's residence or Bhidewada.[1] On 24 September 1873, he, along with his followers, he formed the Satyashodhak Samaj (Society of Seekers of Truth) to attain equal rights for people from lower castes. People from all religions and castes could become a part of this association which worked for the upliftment of the oppressed classes. Phule is regarded as an important figure in the social reform movement in Lagrange.
Early life
Phule was born in 1827 into a family that belonged to the Mali caste, traditionally occupied as gardeners, vegetable vendors, and florists, and considered to be one of the Shudra varnas in the ritual ranking system of Hinduism.[2] The original surname of the family had been Gorhe and had its origins in the village of Katgun, in present-day Satara District, Maharashtra. Phule's great-grandfather worked as a chaugula, a lowly type of village servant, in that village but moved to Khanwadi in Pune district. He prospered there but his only son, Shetiba, who was of poor intelligence, subsequently squandered what had been gained. Shetiba moved himself and his family, including three boys, to Poona in search of some form of income. The boys were taken under the wing of a florist, who taught them his trade. Their proficiency in growing and arranging became well known and they adopted the name of Phule (flower-man) in place of Gorhe.[3] Their fulfillment of commissions from the Peshwa, Baji Rao II, for flower mattresses and other goods for the rituals and ceremonies of the royal court so impressed him that he granted them 35 acres (14 ha) of land on the basis of the inam system, whereby no tax would be payable upon it.[2] The oldest brother machinated to take sole control of the property, leaving the younger two siblings, Jyotirao Phule's father, Govindrao, to continue farming and also flower-selling.[3]

Govindrao married Chimnabai and had two sons, of whom Jyotirao was the younger. Chimnabai died before he was aged one.[3] The Mali community did not make room for much by education, and after attending primary school to learn the basics of reading, writing, and arithmetic, Jyotirao was withdrawn from school. He joined the menfolk of his family at work, both in the shop and the farm. However, a Christian convert from the same Mali caste as Phule recognised his intelligence and persuaded Phule's father to allow Phule to attend the local Scottish Mission High School.[4][5][b] Phule completed his English schooling in 1847. As was customary, he was married young, at the age of 13, to a girl of his own community, chosen by his father.[7]

The turning point in his life was in 1848, when he attended the wedding of a Brahmin friend. Phule participated in the customary marriage procession, but was later rebuked and insulted by his friend's parents for doing that. They told him that he being from a lower caste should have had the sense to keep away from that ceremony. This incident profoundly affected Phule on the injustice of the caste system.[8]

Social activism
Phule's social activism included many fields including eradication of untouchability and the caste system, education of women and the dalits, and welfare of down trodden women.

Education
In 1848, aged 23, Phule visited the first girls' school in Ahmadnagar, run by Christian missionaries. It was also in 1848 that he read Thomas Paine's book Rights of Man and developed a keen sense of social justice. He realized that lower castes and women were at a disadvantage in Indian society, and also that education of these sections was vital to their emancipation.[9]To this end and in the same year, Phule first taught reading and writing to his wife, Savitribai, and then the couple started the first indigenously-run school for girls in Pune.[10][c]In his book Gulamgiri, Phule says that the first school was for Brahmin and upper caste girls, however Phule's biographer says it was for low caste girls.[11]The conservative upper caste society of Pune didn't approve his work. But many Indians and Europeans helped him generously.Conservatives in pune also forced his own family and community to ostracize them.During this period, their friend Usman Sheikh and his sister Fatima Sheikh provided them with roof over their heads.They also helped to start the school in their premises.[12] Later, the Phules started schools for children from the then untouchable castes such as Mahar and Mang.[13] In 1852, there were three Phule schools in operation 273 girls were pursuing education in these school but by 1858 they had all closed. Eleanor Zelliot blames the closure on private European donations drying up due to the Indian Mutiny of 1857, withdrawal of government support, and Jyotirao resigning from the school management committee because of disagreement regarding the curriculum.[14]

Women's welfare
He championed widow remarriage and started a home for high caste pregnant widows to give birth in a safe and secure place in 1863.[15] His orphanage was established in an attempt to reduce the rate of infanticide.[16]

Phule tried to eliminate the stigma of social untouchability surrounding the lower castes by opening his house and the use of his water-well to the members of the lower castes.[17]

Views on religion and caste
Phule recast the prevailing Aryan invasion theory of history, proposing that the Aryan conquerors of India, whom the theory's proponents considered to be racially superior, were in fact barbaric suppressors of the indigenous people. He believed that they had instituted the caste system as a framework for subjugation and social division that ensured the pre-eminence of their Brahmin successors. He saw the subsequent Muslim conquests of the Indian subcontinent as more of the same sort of thing, being a repressive alien regime, but took heart in the arrival of the British, whom he considered to be relatively enlightened and not supportive of the varnashramadharma system instigated and then perpetuated by those previous invaders.[18][d] In his book, Gulamgiri, he thanked Christian missionaries and the British colonists for making the lower castes realise that they are worthy of all human rights.[20] The book, whose title transliterates as slavery and which concerned women, caste and reform, was dedicated to the people in the US who were working to end slavery.[21]

Phule saw Rama, the hero of the Indian epic Ramayana, as a symbol of oppression stemming from the Aryan conquest.[22][23] His critique of the caste system began with an attack on the Vedas, the most fundamental texts of upper-caste Hindus.[24] He considered them to be a form of false consciousness.[25]

He is credited with introducing the Marathi word dalit (broken, crushed) as a descriptor for those people who were outside the traditional varna system. The terminology was later popularised in the 1970s by the Dalit Panthers.[26]

At an education commission hearing in 1884, Phule called for help in providing education for lower castes. To implement it, he advocated making primary education compulsory in villages. He also asked for special incentives to get more lower-caste people in high schools and colleges.[27]

Sathyashodhak Samaj
On 24 September 1873, Phule formed Satyashodhak Samaj to focus on rights of depressed groups such women, the Shudra, and the Dalit.[15][28][29] Through this the samaj he opposed idolatry and denounced the caste system. Satyashodhak Samaj campaigned for the spread of rational thinking and rejected the need for priests.

Phule established Satyashodhak Samaj with the ideals of human well-being, happiness, unity, equality, and easy religious principles and rituals.[29] A Pune-based newspaper, Deenbandhu, provided the voice for the views of the Samaj.[30]

The membership of the samaj included Muslims, Brahmans and government officials. Phule's own Mali caste provided the leading members and financial supporters for the organization.[28]

Occupation
Apart from his role as a social activist, Phule was a businessman too. In 1882 he styled himself as a merchant, cultivator and municipal contractor.[31] He owned 60 acres (24 ha) of farmland at Manjri, near Pune.[32] For period of time, he worked as a contractor for the government and supplied building materials required for the construction of a dam on the Mula-Mutha river near Pune in the 1870s.[citation needed] He also received contracts to provide labour for the construction of the Katraj Tunnel and the Yerawda Jail near Pune.[33] One of Phule's businesses, established in 1863, was to supply metal-casting equipment.[15]

Phule was appointed commissioner (municipal council member) to the then Poona municipality in 1876 and served in this unelected position until 1883.[34]

Published works
Phule's akhandas were organically linked to the abhangs of Marathi Varkari saint Tukaram.[35] Among his notable published works are:

Tritiya Ratna, 1855
Brahmananche Kasab,1869
Powada : Chatrapati Shivajiraje Bhosle Yancha, [English: Life Of Shivaji, In Poetical Metre], June 1869
Powada: Vidyakhatyatil Brahman Pantoji, June 1869
Manav Mahammand (Muhammad) (Abhang)
Gulamgiri, 1873
Shetkarayacha Aasud (Cultivator's Whipcord), July 1881
Satsar Ank 1, June 1885
Satsar Ank 2 June 1885
Ishara, October 1885
Gramjoshya sambhandi jahir kabhar, (1886)
Satyashodhak Samajokt Mangalashtakasah Sarva Puja-vidhi, 1887
Sarvajanik Satya Dharma Poostak, April 1889
Sarvajanic Satya Dharmapustak, 1891
Akhandadi Kavyarachana
Asprashyanchi Kaifiyat

دومينيك راب

دومينيك راب

دومينيك راب (بالإنجليزية: Dominic Raab)‏ هو محامي وسياسي بريطاني، ولد في 25 فبراير 1974 في باكينغهامشير في المملكة المتحدة. حزبياً، نشط في حزب المحافظين.

مناصب
انتخب Secretary of State for Exiting the European Union   (9 يوليو 2018 – 15 نوفمبر 2018).
في انتخابات المملكة المتحدة لعام 2010، انتخب عضو برلمان المملكة المتحدة الـ55 عن دائرة إيشر ووالتن وقد انضم خلال فترته النيابية  (6 مايو 2010 – 30 مارس 2015) للكتلة البرلمانية حزب المحافظين.
في الانتخابات العامة في المملكة المتحدة 2015 ، انتخب عضو برلمان المملكة المتحدة الـ56 عن دائرة إيشر ووالتن وقد انضم خلال فترته النيابية  (8 مايو 2015 – 3 مايو 2017) للكتلة البرلمانية حزب المحافظين.
في الانتخابات التشريعية البريطانية 2017، انتخب عضو برلمان المملكة المتحدة الـ57 عن دائرة إيشر ووالتن وقد انضم خلال فترته النيابية  (8 يونيو 2017 – ) للكتلة البرلمانية حزب المحافظين.

Dominic Raab

Dominic Raab

Dominic Rennie Raab (born 25 February 1974)[1] is a British politician serving as First Secretary of State and Secretary of State for Foreign and Commonwealth Affairs since July 2019. A member of the Conservative Party, he has also been the Member of Parliament (MP) for Esher and Walton since 2010.

Raab was appointed Parliamentary Under-Secretary of State at the Ministry of Justice on 12 May 2015. When Prime Minister Theresa May appointed her first government a year later, he returned to the backbenches. Following the 2017 general election, he was appointed Minister of State for Courts and Justice. When the government was reshuffled in January 2018, Raab moved to the Ministry of Housing, Communities and Local Government.[2]

In July 2018, May promoted Raab to his first Cabinet role, becoming Secretary of State for Exiting the European Union following the resignation of David Davis.[3] Raab resigned as Brexit Secretary four months later, in opposition to the Draft Withdrawal Agreement which he had been involved in negotiating with the EU.[4]

After May announced her resignation in May 2019, Raab ran to succeed her in the Conservative Party leadership election. He was eliminated in the second ballot of Conservative MPs and endorsed Boris Johnson, who went on to win. On 24 July 2019, Johnson appointed Raab Secretary of State for Foreign and Commonwealth Affairs and First Secretary of State.
Early life and education
Born in Buckinghamshire in 1974,[5] Raab is the son of Jean, a clothes buyer, and Peter Raab, a food manager for Marks & Spencer. His father, who was Jewish, came to Britain from Czechoslovakia in 1938 aged six, following the Munich Agreement, which gave parts of Czechoslovakia to Nazi Germany.[6][7][8][9] Raab was brought up in his English mother's faith, in the Church of England.[6] He grew up in Gerrards Cross, Buckinghamshire.[10] Raab was twelve years old when his father died of cancer.[citation needed]

Raab attended Dr Challoner's Grammar School, Amersham before studying law at Lady Margaret Hall, Oxford, graduating with a Bachelor of Arts in Jurisprudence. Raab captained the university karate team and shared accommodation facilities with future Channel 4 News presenter Cathy Newman. He then pursued further studies at Jesus College, Cambridge, where he won the Clive Parry Prize for International Law, and took a Master's degree (LLM).[11][12][13]

Early career
After leaving Cambridge, Raab worked at Linklaters in London, completing his two-year training contract at the firm and then leaving shortly after qualifying as a solicitor in 2000. At Linklaters he worked on project finance, international litigation and competition law. This included time on secondments at Liberty (the human rights NGO) and in Brussels advising on EU and WTO law.[14][third-party source needed] He spent the summer of 1998 at Birzeit University near Ramallah, the PNA's capital in the West Bank, where he worked for one of the principal PLO negotiators of the Oslo peace accords, assessing World Bank projects on the West Bank.

Raab joined the Foreign Office in 2000, covering a range of briefs including leading a team at the British Embassy in The Hague, dedicated to bringing war criminals to justice. After returning to London, he advised on the Arab–Israeli conflict, the European Union and Gibraltar. He defended Tony Blair against a subpoena from former Yugoslav President Slobodan Milošević. From 2006 to 2010, he worked in Parliament as Chief of Staff to Shadow Home Secretary David Davis and to Shadow Secretary of State for Justice Dominic Grieve.

Parliamentary career
Member of Parliament
Raab was elected to Parliament at the 2010 election to represent Esher and Walton, a safe Conservative seat in Surrey, with a total of 32,134 votes (58.9% of the vote)[15] and a majority of 18,593 over his nearest rival.[15]

He lives in and commutes from Thames Ditton, in his constituency. Since being elected he has campaigned for fairer funding for local services in Elmbridge, stronger local democracy in the running of community hospitals in Cobham, Walton and Molesey and more visible and responsive policing, and against the construction of an M25 service station at Downside.[16]

In the House of Commons, Raab spoke in support of the coalition government's plans to cut the budget deficit, expand academy schools, repeal the Identity Cards Act 2006, and enact a Freedom Bill.[17] He criticised the government for opting into the EU directive on the European Investigation Order, arguing it would strain operational policing resources, and would dilute safeguards protecting British citizens from misuse of personal data and guaranteeing a fair trial.[18]

He came to media attention in August 2010, after requesting that the pressure group 38 Degrees remove his parliamentary email address from their website, arguing that lobby groups sending or coordinating 'clone emails' designed to deluge MP's inboxes detracted from their ability to correspond with constituents and help those in real need. 38 Degrees said that the email address is paid for by taxpayers' money and is in the public domain, thus they have every right to host it on their website and use it for campaigning.[19][20]

Raab has participated in debates on giving prisoners the vote and extradition. In April 2011, he also presented an ultimately unsuccessful Ten Minute Rule Bill proposing that emergency service and transport unions should be required by law to ensure that strike votes receive 50% support of union members. Raab argued that reform was needed to prevent "militant union bosses" holding the "hard working majority" to ransom.
On 7 March 2012, Raab opened a debate in the House of Commons on Sergei Magnitsky and Impunity for Gross Human Rights Abuses, calling on the UK government to bring forward legislative proposals that would allow it to impose visa bans and asset freezes on state officials responsible for gross human rights abuses against individuals. The motion was supported by three former Foreign Secretaries and two former Foreign Ministers and had cross-party support[23] and was passed unanimously by MPs.[24]

On 30 January 2014, Raab proposed an amendment to the Immigration Bill to deport all prisoners given a sentence of a year or more. It was defeated, but allowed 99 members to voice that change was necessary to prevent immigrants convicted of crimes from using the ECHR as support to remain in the UK.[25]

In the 2015 general election on 7 May, Raab retained his Esher and Walton seat with a majority of 28,000 votes over his nearest rival.[26] On 12 May, he was appointed Parliamentary Under-Secretary of State at the Ministry of Justice under Michael Gove, with responsibility for human rights questions.[27] In September 2015, in this capacity, he addressed representatives of the 46 other member states of the Council of Europe on the question of the UK's blanket ban on prisoner voting.[28]

In the 2017 general election, Raab was elected with a reduced majority of 23,000.[29]

Libel case
On 30 January 2011, The Mail on Sunday published an article alleging that Raab, in his previous role as Chief of Staff to David Davis in 2007, had paid a female employee £20,000 in an out-of-court settlement as part of a confidentiality agreement to drop a claim of workplace bullying. Raab responded by stating: "This is a smear and any insinuation that I have behaved improperly is false and malicious". He subsequently sued the newspaper for libel. The Mail on Sunday's publisher Associated Newspapers' attempt to stop the action was denied by the High Court in December 2011.[30]

During these proceedings, it was disclosed that the employee had taken a claim against Raab to an employment tribunal, where it was settled with a compromise agreement which included monetary compensation and a confidentiality clause for both parties.[31][32] The newspaper issued an apology on 18 March 2012, stating: "We accept that our allegations were unfounded and we apologise to Mr Raab for the damage, embarrassment and offence caused".[33][34]

Westminster dossier
In late October 2017, a dossier listing allegations of a mainly sexual nature against several dozen Conservative MPs made internally by party researchers was circulated at Westminster and amongst journalists.[35] Raab wrote on his website at the beginning of November that his entry made a false accusation of an "Injunction for inappropriate behaviour with a woman".[36] He commented: "I have never been served with any injunction for anything. Nor have I ever sought one". It was "false and malicious" to make "any insinuation that I have engaged in anything resembling sexual harassment, sexually abusive behaviour or lewd remarks". He believed the dossier itself was a "form of harassment and intimidation".[36] Raab said he was taking legal advice.[35]

Unpaid internship advertisement
In February 2018, Raab advertised for an unpaid intern just ahead of a Department for Business, Energy and Industrial Strategy (BEIS) publication responding to the Taylor review on insecure work. The BEIS report criticised "exploitative unpaid internships", saying "an employer cannot avoid paying someone the minimum wage simply by calling them an 'intern' or saying that they are doing an internship."[37]

Impact of immigration on the housing market
In April 2018, Raab said in an interview that immigration had "put house prices up by something like 20%" over the past 25 years.[38] The UK Statistics Authority asked Raab to publish the evidence for his claim. A document published by the Ministry of Housing, Communities and Local Government shows that the finding was based on an out-of-date model that had never been intended for this kind of analysis. Raab defended the model and said: "I did indeed say care was needed with the data, and I was right that immigration put average prices up by 20%. We need a balanced approach."[39]

EU referendum campaign
Raab was an active campaigner in the 2016 EU membership referendum, advocating that Britain should leave the European Union. He said in an interview that it would be better for the British economy to leave: "We'll be better off if we're freed up to trade more energetically with the growth markets like Latin America and Asia. I think it will be good for job creation and also cut prices in the stores." He also argued that there was too much waste and corruption in the EU.[40] During the Brexit campaign, Raab repeatedly argued that there was no doubt that the UK would get a deal with the EU.[41]

Brexit Secretary
On 9 July 2018, following the resignation of David Davis, Raab was appointed Secretary of State for Exiting the European Union.[42]

In November 2018, Raab was criticised by Labour's shadow Brexit minister, Jenny Chapman, after Raab said that he "hadn't quite understood the full extent" of how much UK trade relies on the Dover-Calais crossing.[43][44]

In June 2019 EU sources claimed that he had been nicknamed "The Turnip" in Brussels, a play on raap, the Dutch word for the vegetable, insinuating EU dissatisfaction with his negotiation strategy.[45]

On 15 November 2018, Raab announced his resignation as Brexit Secretary, citing his disapproval over the Cabinet position on the draft Brexit withdrawal agreement.[46] According to a BBC News report, Raab was concerned with "two major and fatal flaws" in the draft agreement, namely that the proposed terms "threaten the integrity of the United Kingdom" and that "they would lead to an indefinite if not permanent situation where [the UK is] locked into a regime with no say over the rules being applied, with no exit mechanism", flaws which would prove "damaging for the economy [and] devastating for public trust in our democracy".[47] While subsequently describing May's deal as worse than remaining in the EU,[48] he voted in favour of it at the occasion of the third vote on the withdrawal agreement on 29 March 2019.[49] While thus voting in favour of the Irish backstop, as Foreign Secretary he subsequently described the backstop as "undemocratic and [...] something that will have to be removed."[50]

Following his resignation, Raab has defended the position that the UK should not pay the so-called Brexit divorce bill (amounting to around £39 billion) in the event of a no-deal Brexit.[51] This bill reflects commitments which the UK entered into for the EU's Multiannual Financial Framework for the years 2014–2020 and so according to some interpretations is not linked to Britain's exit from the European Union.[52] The House of Lords alternatively has found that the UK would not be liable for such payments.[53]

2019 Conservative Party leadership election
On 25 May 2019, Raab announced he was standing in the Conservative Party leadership election after Theresa May announced her resignation.[54] In the second round of voting, on 18 June, Raab failed to obtain the required minimum number of 33 votes, winning 30 and finishing in sixth place, behind Sajid Javid.[55] After being eliminated, he endorsed the frontrunner Boris Johnson,[56] who subsequently won the contest.

Foreign Secretary and First Secretary of State
On 24 July 2019, Boris Johnson appointed Raab Foreign Secretary, succeeding Jeremy Hunt, and handed him the additional title First Secretary of State.[57] On arrival at the Foreign Office, Raab said: "I'm hugely humbled to take on this role at this time and excited about the opportunities that lie ahead."[58]

Shortly after his appointment, during an interview with Mishal Husain, Raab argued that the 2016 Brexit referendum had given the government a mandate to leave without a deal. Following the interview, the BBC reported that the Twitter accounts of Raab, Michael Gove, and the official Vote Leave campaign made no reference to leaving the EU without a deal in the six months leading up to the Brexit vote.[41]

Raab stood in for Boris Johnson at Prime Minister's Questions on 2 October 2019, as First Secretary of State.[59]

On 3 January 2020, the high-level Iranian General, Qasem Soleimani, was assassinated by the United States, which considerably heightened the existing tensions between the two countries. Raab backed the strike, describing the American action as self-defence.[60] He noted that his government had "always recognized the aggressive threat posed by the Iranian Quds force".[61]

Raab supported Boris Johnson's decision to allow China's Huawei to build part of UK's 5G network despite U.S. and Australian opposition.[62][63]

On 23 March, during the coronavirus pandemic, the government confirmed that Raab, as First Secretary of State, was to deputise for Boris Johnson if he became "incapacitated" due to COVID-19.[64] On 6 April, after Johnson was admitted to an intensive care unit due to his illness with COVID-19, Raab was asked to deputise for Johnson.[65]

Political positions
Positive discrimination
In July 2010, he secured a review of positive discrimination rules being applied to Foreign and Commonwealth Office work experience schemes, having been contacted by a constituent who had been rejected from the scheme for failing to meet "the social criteria". The two programmes at the organisation barred white males from applying, other than those from low-income backgrounds; Raab argued they re-introduced discrimination 'via the backdoor'.[66] The MP welcomed the review, blaming the situation on the previous Labour government. He stated "positive discrimination is wrong in the same way as negative discrimination. It means people are thinking in terms of social criteria and it is anti-meritocratic."[67]

Palestinian state
In 2011, Raab wrote that "Israeli settlement building undermined prospects for a contiguous Palestinian state."[68]

Prisoners' rights
On 10 February 2011, Raab gave the winding-up speech in the debate on whether to give prisoners the vote, arguing that freedom entails responsibility and that elected lawmakers in the House of Commons rather than "unaccountable" judges in Strasbourg should decide the matter.[69][70]

On 22 June 2011, the Joint Committee on Human Rights (JCHR) published a report on The Human Rights Implications of British extradition.[71] As a member of the JCHR, Raab proposed that the committee looks into the issue of fast-track extradition of British citizens following several instances of miscarriages of justice. In an article for The Times,[72] Raab argued that more needed to be done to protect British citizens subject to European Arrest Warrants. The JCHR has called for safeguards to ensure warrants are not issued for minor offences and when there is minimal evidence, and for checks to prevent extradition for investigation rather than prosecution. On 24 November 2011, Raab led a debate in the House of Commons calling for extradition reform.[73] His motion had cross-party support, and was backed by Gary McKinnon's mother, Janis Sharpe.[74][75]

The Miller case
On 3 November 2016, and in response to the decision of the High Court in R (Miller) v Secretary of State for Exiting the European Union on whether Her Majesty's Government was entitled to notify an intention to leave the European Union under Article 50 of the Treaty on European Union without a vote in Parliament, Raab stated that in the 2016 EU membership referendum "the British people gave a clear mandate for the UK Government to leave the EU and take back control of our borders, laws, money and trade. It is disappointing that today the court has chosen to ignore their decision". He went on to state that the decision was "a plain attempt to block Brexit by people who are out of touch with the country and refuse to accept the result. However, the vote to leave the EU was clear and they should not seek to obstruct it".[76]

Saudi Arabia
In October 2018, Raab told BBC One's The Andrew Marr Show that the assassination of Jamal Khashoggi was a "terrible case" but the UK government was "not throwing our hands in the air and terminating the relationship with Saudi Arabia, not just because of the huge number of British jobs that depend on it but also because if you exert influence over your partners you need to be able to talk to them... The problem with Labour's position is it would cost thousands of British jobs."[77][78]

Writings
Civil liberties and justice
In 2009, Raab published his first book, The Assault on Liberty – What Went Wrong with Rights.[79] In October 2010, he published Fight Terror, Defend Freedom, a pamphlet on the Home Office counter-terrorism review.[80]

In January 2011, Raab wrote an article on the use of control orders in counter-terrorism cases in which he contended that they are ineffective and should be scrapped with a greater focus on prosecutions.[81]

Raab published a pamphlet with the think tank Civitas entitled Strasbourg in the Dock[82] in April 2011. The pamphlet followed Parliament's recent rejection of a European Court of Human Rights ruling (the Hirst case) that at least some prisoners should have the right to vote. Raab argued that unelected judges had overstepped the mark in relation to the case. The Strasbourg judges are elected by the 324 members of the Parliamentary Assembly of the Council of Europe, though this is itself not an elected body. Raab contended that many of the judges were lacking experience and as a result "are undermining the credibility and value of the Court".[83] Raab made a range of proposals to strengthen the authority of Britain's Supreme Court, give elected lawmakers the last word on the creation of new rights, and reform the Strasbourg Court.

In July 2011, Raab called for reform of the UK Borders Act 2007 which allows foreign criminals to avoid deportation by claiming a "right to family life" under Article 8 of the European Convention on Human Rights. He proposed that the reference to the Human Rights Act be removed. He argued this could be done in a way that ensures foreign criminals could avoid deportation only if there is a "serious risk" they will be tortured on their return.[84]

Equality, meritocracy and positive discrimination
On 30 January 2011, he wrote a comment piece for The Sunday Times on the implementation of the Equality Act. Raab argued for a meritocratic approach against positive discrimination and highlighted the lower standard of human rights protections in extradition cases compared to deportation cases.[85]

In an article in January 2011 on the Politics Home website, Raab argued in favour of transferable paternity leave and against "the equality bandwagon" "pitting men and women against each other". He argued in favour of a consistent approach to sexism against men and women commenting that some feminists were "now amongst the most obnoxious bigots" and it was sexist to blame men for the recession.[86]

Raab highlighted the wide range of sex discrimination faced by males including "anti-male discrimination in rights of maternity/paternity leave", young boys being "educationally disadvantaged compared to girls", and how "divorced or separated fathers are systematically ignored by the courts". Raab stated "from the cradle to the grave, men are getting a raw deal. Men work longer hours, die earlier, but retire later than women", noting that the pensions inequalities were still not going to be rectified for another seven years.[87][88]

He was subsequently interviewed on the piece by the London Evening Standard[89] and BBC Radio 4.[90] Theresa May, who was Minister for Women and Equalities at the time, criticised Raab's "obnoxious bigots" comment but agreed with his suggestions on paternity leave and ending gender warfare.[91][92] Her remarks took place during a debate on employment law in the Commons.[93]

Raab's remarks were criticised by some Labour MPs, including Harriet Harman and Nia Griffith, who said Raab should "stop being so self-pitying. The reality is that women with very good qualifications time and time again do not get the top jobs and opportunities."[94] Raab stood by his comments in a comment piece for The Telegraph, highlighting the various statements Harman had made about men, contrasting them with similar comments about women by the likes of Andy Gray.[95] Raab also stated he had received an "overwhelmingly positive" reaction to his comments "from both men and women".[96]

In July 2012, Raab published a pamphlet with the Centre for Policy Studies entitled Unleashing the British Underdog: 10 Bets on the Little Guy. In the report, Raab outlines 10 policies to improve social mobility and provide opportunities for those from non-traditional backgrounds to succeed.[97]

After the Coalition
In October 2011, Dominic Raab and four other MPs of the 2010 intake published After the Coalition, an argument that Conservative principles adapted to the modern world would be essential for the future national success of the party. The book was serialised in The Daily Telegraph. Raab wrote his piece for the paper on British foreign policy, arguing it should reflect the national interest: Britain should not overextend itself in foreign conflicts, aid should be focused on the poorest countries and Britain should champion free trade abroad.[98]

Regulation
In November 2011, Raab wrote a pamphlet published by the Centre for Policy Studies, Escaping the Strait Jacket – Ten Regulatory Reforms to Create Jobs. The paper makes the case for reforming red tape to boost job creation on grounds of economic competitiveness and social fairness.[99]

Britannia Unchained
In September 2012 Raab co-authored the book Britannia Unchained. The book addressed issues of the national debt, state education, innovation and work ethic.

Raab called for measures to cut regulation on start-up companies, expand vocational training, reduce childcare costs and lower marginal (income-focused) rates of taxation to "rediscover and reward the lost virtue of hard-work – a tried and tested route to individual success, a more prosperous economy and a fairer society."[100]

Writing on work ethic in The Daily Telegraph, Raab said that longer periods in education, earlier retirement, welfare dependency and high marginal rates of taxation had led to a situation where "(w)e have a smaller proportion of the workforce pedalling harder to sustain the rest – which is economically debilitating and socially divisive."[100]

Personal life
Raab is married to Erika Rey, a Brazilian marketing executive who until 2020 worked for Google.[101] They have two children,[13] and live in Thames Ditton, Surrey.[102]

Raab holds a black belt, third Dan in karate.[6]

Awards
Raab won Newcomer of the Year for 2011 at The Spectator magazine's Parliamentary Awards.[103]

In 2019, LBC's Iain Dale and a "panel of experts" placed Raab fourth in a list of that year's 'Top 100 Most Influential Conservatives'

Georgia Groome

Georgia Groome

Georgia Groome is an English actress. She is best known for her roles in London to Brighton (2006) and Angus, Thongs and Perfect Snogging (2008).
arly life and education
Groome was born on 11 February 1992[1] in Nottingham,[2] the daughter of Paul Groome, a publican and chef who died in 2009, and Fiona (née Tulloch), a drama and vocal coach.
She resided in Chellaston near Shelton Lock, Derbyshire.[citation needed] Groome, at the age of nine, auditioned for a role in the touring stage version of the musical Annie Get Your Gun and got the part
She trained at Nottingham Television Workshop, Derby Youth Theatre. and Trent College.[3]

Career
After her acting debut in the TV film, A Fish Out of Water in 2001, Groome appeared in an episode of the short-lived TV series, Dangerville, playing an orphan.

When Groome was just 14 years old, she landed her first feature film role in the well-received British independent film London to Brighton in 2006, playing an 11-year-old runaway.[4] That year she was also one of the eight young adventurers on Serious Amazon for CBBC.[5] In 2007 Groome had a role in Elaine Wickham's short, My Mother.

In 2008, Groome had a minor role in comedy, horror The Cottage. Her breakthrough role was as 14-year-old, boyfriend-searching Georgia Nicolson alongside Aaron Johnson in the 2008 film Angus, Thongs and Perfect Snogging, for which she won the award for Best Child Actor at the Buster International Children's Film Festival.[1] She also had a minor role in horror film The Disappeared.

In 2009, she made her stage debut in Tusk Tusk, a new play by Polly Stenham at the Royal Court Theatre in London.[1][6] The same year, she appeared in the short Leaving Eva and an episode of The Bill. In 2010, Groome appeared in an episode of British television detective drama Lewis, as well as the short Silent Things.

In 2011, Groome starred in two shorts, The True Meaning of Love[7] and Six Degrees. She also appeared in Susan Jacobson's The Holding[8] and had a lead role in The Great Ghost Rescue, a film adaptation of Eva Ibbotson's book of the same name.[9]

She appeared alongside Stephen Dillane in Papadopoulos & Sons, in which she played snobby fashion victim Katie. The film was released in the UK through Cineworld on 5 April 2013.

Personal life
Groome has been in a relationship with Rupert Grint since 2011.[10] On April 10, 2020, it was announced that Grint and Groome were expecting their first child.

Ebola

Ebola

Ebola virus disease (EVD), or simply Ebola, is a viral haemorrhagic fever of humans and other primates caused by ebolaviruses.[1] Signs and symptoms typically start between two days and three weeks after contracting the virus with a fever, sore throat, muscular pain, and headaches.[1] Vomiting, diarrhoea and rash usually follow, along with decreased function of the liver and kidneys.[1] At this time, some people begin to bleed both internally and externally.[1] The disease has a high risk of death, killing 25% to 90% of those infected, with an average of about 50%.[1] This is often due to low blood pressure from fluid loss, and typically follows six to 16 days after symptoms appear.[2]

The virus spreads through direct contact with body fluids, such as blood from infected humans or other animals.[1] Spread may also occur from contact with items recently contaminated with bodily fluids.[1] Spread of the disease through the air between primates, including humans, has not been documented in either laboratory or natural conditions.[3] Semen or breast milk of a person after recovery from EVD may carry the virus for several weeks to months.[1][4][5] Fruit bats are believed to be the normal carrier in nature, able to spread the virus without being affected by it.[1] Other diseases such as malaria, cholera, typhoid fever, meningitis and other viral haemorrhagic fevers may resemble EVD.[1] Blood samples are tested for viral RNA, viral antibodies or for the virus itself to confirm the diagnosis.[1][6]

Control of outbreaks requires coordinated medical services and community engagement.[1] This includes rapid detection, contact tracing of those who have been exposed, quick access to laboratory services, care for those infected, and proper disposal of the dead through cremation or burial.[1][7] Samples of body fluids and tissues from people with the disease should be handled with special caution.[1] Prevention includes limiting the spread of disease from infected animals to humans by handling potentially infected bushmeat only while wearing protective clothing, and by thoroughly cooking bushmeat before eating it.[1] It also includes wearing proper protective clothing and washing hands when around a person with the disease.[1] An Ebola vaccine was approved in the United States in December 2019.[8] While there is no approved treatment for Ebola as of 2019,[9] two treatments (REGN-EB3 and mAb114) are associated with improved outcomes.[10] Supportive efforts also improve outcomes.[1] This includes either oral rehydration therapy (drinking slightly sweetened and salty water) or giving intravenous fluids as well as treating symptoms.[1]

The disease was first identified in 1976, in two simultaneous outbreaks: one in Nzara (a town in South Sudan) and the other in Yambuku (Democratic Republic of the Congo), a village near the Ebola River from which the disease takes its name.[1] EVD outbreaks occur intermittently in tropical regions of sub-Saharan Africa.[1] Between 1976 and 2013, the World Health Organization reports 24 outbreaks involving 2,387 cases with 1,590 deaths.[1][11] The largest outbreak to date was the epidemic in West Africa, which occurred from December 2013 to January 2016, with 28,646 cases and 11,323 deaths.[12][13][14] It was declared no longer an emergency on 29 March 2016.[15] Other outbreaks in Africa began in the Democratic Republic of the Congo in May 2017,[16][17] and 2018.[18][19] In July 2019, the World Health Organization declared the Congo Ebola outbreak a world health emergency.[20]
Onset
The length of time between exposure to the virus and the development of symptoms (incubation period) is between two and 21 days,[1][21] and usually between four and ten days.[22] However, recent estimates based on mathematical models predict that around 5% of cases may take greater than 21 days to develop.[23]

Symptoms usually begin with a sudden influenza-like stage characterised by feeling tired, fever, weakness, decreased appetite, muscular pain, joint pain, headache, and sore throat.[1][22][24][25] The fever is usually higher than 38.3 °C (101 °F).[26] This is often followed by nausea, vomiting, diarrhoea, abdominal pain, and sometimes hiccups.[25][27] The combination of severe vomiting and diarrhoea often leads to severe dehydration.[28] Next, shortness of breath and chest pain may occur, along with swelling, headaches, and confusion.[25] In about half of the cases, the skin may develop a maculopapular rash, a flat red area covered with small bumps, five to seven days after symptoms begin.[22][26]

Bleeding
In some cases, internal and external bleeding may occur.[1] This typically begins five to seven days after the first symptoms.[29] All infected people show some decreased blood clotting.[26] Bleeding from mucous membranes or from sites of needle punctures has been reported in 40–50% of cases.[30] This may cause vomiting blood, coughing up of blood, or blood in stool.[31] Bleeding into the skin may create petechiae, purpura, ecchymoses or haematomas (especially around needle injection sites).[32] Bleeding into the whites of the eyes may also occur.[33] Heavy bleeding is uncommon; if it occurs, it is usually in the gastrointestinal tract.[34] The incidence of bleeding into the gastrointestinal tract was reported to be ~58% in the 2001 outbreak in Gabon,[35] but in the 2014-15 outbreak in the US it was ~18%,[36] possibly due to improved prevention of disseminated intravascular coagulation.[28]

Recovery and death
Recovery may begin between seven and 14 days after first symptoms.[25] Death, if it occurs, follows typically six to sixteen days from first symptoms and is often due to low blood pressure from fluid loss.[2] In general, bleeding often indicates a worse outcome, and blood loss may result in death.[24] People are often in a coma near the end of life.[25]

Those who survive often have ongoing muscular and joint pain, liver inflammation, and decreased hearing, and may have continued tiredness, continued weakness, decreased appetite, and difficulty returning to pre-illness weight.[25][37] Problems with vision may develop.[38]

Survivors develop antibodies against Ebola that last at least 10 years, but it is unclear whether they are immune to additional infections.[39]

Cause
EVD in humans is caused by four of five viruses of the genus Ebolavirus. The four are Bundibugyo virus (BDBV), Sudan virus (SUDV), Taï Forest virus (TAFV) and one simply called Ebola virus (EBOV, formerly Zaire Ebola virus).[40] EBOV, species Zaire ebolavirus, is the most dangerous of the known EVD-causing viruses, and is responsible for the largest number of outbreaks.[41] The fifth virus, Reston virus (RESTV), is not thought to cause disease in humans, but has caused disease in other primates.[42][43] All five viruses are closely related to marburgviruses.[40]

Virology
Ebolaviruses contain single-stranded, non-infectious RNA genomes.[44] Ebolavirus genomes contain seven genes including 3'-UTR-NP-VP35-VP40-GP-VP30-VP24-L-5'-UTR.[32][45] The genomes of the five different ebolaviruses (BDBV, EBOV, RESTV, SUDV and TAFV) differ in sequence and the number and location of gene overlaps. As with all filoviruses, ebolavirus virions are filamentous particles that may appear in the shape of a shepherd's crook, of a "U" or of a "6," and they may be coiled, toroid or branched.[45][46] In general, ebolavirions are 80 nanometers (nm) in width and may be as long as 14,000 nm.[47]

Their life cycle is thought to begin with a virion attaching to specific cell-surface receptors such as C-type lectins, DC-SIGN, or integrins, which is followed by fusion of the viral envelope with cellular membranes.[48] The virions taken up by the cell then travel to acidic endosomes and lysosomes where the viral envelope glycoprotein GP is cleaved.[48] This processing appears to allow the virus to bind to cellular proteins enabling it to fuse with internal cellular membranes and release the viral nucleocapsid.[48] The Ebolavirus structural glycoprotein (known as GP1,2) is responsible for the virus' ability to bind to and infect targeted cells.[49] The viral RNA polymerase, encoded by the L gene, partially uncoats the nucleocapsid and transcribes the genes into positive-strand mRNAs, which are then translated into structural and nonstructural proteins. The most abundant protein produced is the nucleoprotein, whose concentration in the host cell determines when L switches from gene transcription to genome replication. Replication of the viral genome results in full-length, positive-strand antigenomes that are, in turn, transcribed into genome copies of negative-strand virus progeny.[50] Newly synthesised structural proteins and genomes self-assemble and accumulate near the inside of the cell membrane. Virions bud off from the cell, gaining their envelopes from the cellular membrane from which they bud. The mature progeny particles then infect other cells to repeat the cycle. The genetics of the Ebola virus are difficult to study because of EBOV's virulent characteristics.[51]

Transmission
It is believed that between people, Ebola disease spreads only by direct contact with the blood or other body fluids of a person who has developed symptoms of the disease.[52][53][54] Body fluids that may contain Ebola viruses include saliva, mucus, vomit, feces, sweat, tears, breast milk, urine and semen.[4][39] The WHO states that only people who are very sick are able to spread Ebola disease in saliva, and whole virus has not been reported to be transmitted through sweat. Most people spread the virus through blood, feces and vomit.[55] Entry points for the virus include the nose, mouth, eyes, open wounds, cuts and abrasions.[39] Ebola may be spread through large droplets; however, this is believed to occur only when a person is very sick.[56] This contamination can happen if a person is splashed with droplets.[56] Contact with surfaces or objects contaminated by the virus, particularly needles and syringes, may also transmit the infection.[57][58] The virus is able to survive on objects for a few hours in a dried state, and can survive for a few days within body fluids outside of a person.[39][59]

The Ebola virus may be able to persist for more than three months in the semen after recovery, which could lead to infections via sexual intercourse.[4][60][61] Virus persistence in semen for over a year has been recorded in a national screening programme.[62] Ebola may also occur in the breast milk of women after recovery, and it is not known when it is safe to breastfeed again.[5] The virus was also found in the eye of one patient in 2014, two months after it was cleared from his blood.[63] Otherwise, people who have recovered are not infectious.[57]

The potential for widespread infections in countries with medical systems capable of observing correct medical isolation procedures is considered low.[64] Usually when someone has symptoms of the disease, they are unable to travel without assistance.[65]

Dead bodies remain infectious; thus, people handling human remains in practices such as traditional burial rituals or more modern processes such as embalming are at risk.[64] 69% of the cases of Ebola infections in Guinea during the 2014 outbreak are believed to have been contracted via unprotected (or unsuitably protected) contact with infected corpses during certain Guinean burial rituals.[66][67]

Health-care workers treating people with Ebola are at greatest risk of infection.[57] The risk increases when they do not have appropriate protective clothing such as masks, gowns, gloves and eye protection; do not wear it properly; or handle contaminated clothing incorrectly.[57] This risk is particularly common in parts of Africa where the disease mostly occurs and health systems function poorly.[68] There has been transmission in hospitals in some African countries that reuse hypodermic needles.[69][70] Some health-care centres caring for people with the disease do not have running water.[71] In the United States the spread to two medical workers treating infected patients prompted criticism of inadequate training and procedures.[72]

Human-to-human transmission of EBOV through the air has not been reported to occur during EVD outbreaks,[3] and airborne transmission has only been demonstrated in very strict laboratory conditions, and then only from pigs to primates, but not from primates to primates.[52][58] Spread of EBOV by water, or food other than bushmeat, has not been observed.[57][58] No spread by mosquitos or other insects has been reported.[57] Other possible methods of transmission are being studied.[59]

Airborne transmission among humans is theoretically possible due to the presence of Ebola virus particles in saliva, which can be discharged into the air with a cough or sneeze, but observational data from previous epidemics suggests the actual risk of airborne transmission is low.[73] A number of studies examining airborne transmission broadly concluded that transmission from pigs to primates could happen without direct contact because, unlike humans and primates, pigs with EVD get very high ebolavirus concentrations in their lungs, and not their bloodstream.[74] Therefore, pigs with EVD can spread the disease through droplets in the air or on the ground when they sneeze or cough.[75] By contrast, humans and other primates accumulate the virus throughout their body and specifically in their blood, but not very much in their lungs.[75] It is believed that this is the reason researchers have observed pig to primate transmission without physical contact, but no evidence has been found of primates being infected without actual contact, even in experiments where infected and uninfected primates shared the same air.[74][75]

Initial case
Although it is not entirely clear how Ebola initially spreads from animals to humans, the spread is believed to involve direct contact with an infected wild animal or fruit bat.[57] Besides bats, other wild animals sometimes infected with EBOV include several monkey species, chimpanzees, gorillas, baboons, and duikers.[79]

Animals may become infected when they eat fruit partially eaten by bats carrying the virus.[80] Fruit production, animal behavior and other factors may trigger outbreaks among animal populations.[80]

Evidence indicates that both domestic dogs and pigs can also be infected with EBOV.[81] Dogs do not appear to develop symptoms when they carry the virus, and pigs appear to be able to transmit the virus to at least some primates.[81] Although some dogs in an area in which a human outbreak occurred had antibodies to EBOV, it is unclear whether they played a role in spreading the disease to people.[81]

Reservoir
The natural reservoir for Ebola has yet to be confirmed; however, bats are considered to be the most likely candidate species.[58] Three types of fruit bats (Hypsignathus monstrosus, Epomops franqueti and Myonycteris torquata) were found to possibly carry the virus without getting sick.[82] As of 2013, whether other animals are involved in its spread is not known.[81] Plants, arthropods, rodents, and birds have also been considered possible viral reservoirs.[1][28]

Bats were known to roost in the cotton factory in which the first cases of the 1976 and 1979 outbreaks were observed, and they have also been implicated in Marburg virus infections in 1975 and 1980.[83] Of 24 plant and 19 vertebrate species experimentally inoculated with EBOV, only bats became infected.[84] The bats displayed no clinical signs of disease, which is considered evidence that these bats are a reservoir species of EBOV. In a 2002–2003 survey of 1,030 animals including 679 bats from Gabon and the Republic of the Congo, 13 fruit bats were found to contain EBOV RNA.[85] Antibodies against Zaire and Reston viruses have been found in fruit bats in Bangladesh, suggesting that these bats are also potential hosts of the virus and that the filoviruses are present in Asia.[86]

Between 1976 and 1998, in 30,000 mammals, birds, reptiles, amphibians and arthropods sampled from regions of EBOV outbreaks, no Ebola virus was detected apart from some genetic traces found in six rodents (belonging to the species Mus setulosus and Praomys) and one shrew (Sylvisorex ollula) collected from the Central African Republic.[83][87] However, further research efforts have not confirmed rodents as a reservoir.[88] Traces of EBOV were detected in the carcasses of gorillas and chimpanzees during outbreaks in 2001 and 2003, which later became the source of human infections. However, the high rates of death in these species resulting from EBOV infection make it unlikely that these species represent a natural reservoir for the virus.[83]

Deforestation has been mentioned as a possible contributor to recent outbreaks, including the West African Ebola virus epidemic. Index cases of EVD have often been close to recently deforested lands.[89][90]

Pathophysiology
Like other filoviruses, EBOV replicates very efficiently in many cells, producing large amounts of virus in monocytes, macrophages, dendritic cells and other cells including liver cells, fibroblasts, and adrenal gland cells.[91] Viral replication triggers high levels of inflammatory chemical signals and leads to a septic state.[37]

EBOV is thought to infect humans through contact with mucous membranes or skin breaks.[52] After infection, endothelial cells (cells lining the inside of blood vessels), liver cells, and several types of immune cells such as macrophages, monocytes, and dendritic cells are the main targets of attack.[52] Following infection, immune cells carry the virus to nearby lymph nodes where further reproduction of the virus takes place.[52] From there the virus can enter the bloodstream and lymphatic system and spread throughout the body.[52] Macrophages are the first cells infected with the virus, and this infection results in programmed cell death.[47] Other types of white blood cells, such as lymphocytes, also undergo programmed cell death leading to an abnormally low concentration of lymphocytes in the blood.[52] This contributes to the weakened immune response seen in those infected with EBOV.[52]

Endothelial cells may be infected within three days after exposure to the virus.[47] The breakdown of endothelial cells leading to blood vessel injury can be attributed to EBOV glycoproteins. This damage occurs due to the synthesis of Ebola virus glycoprotein (GP), which reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes liver damage, leading to improper clotting. The widespread bleeding that occurs in affected people causes swelling and shock due to loss of blood volume.[92] The dysfunctional bleeding and clotting commonly seen in EVD has been attributed to increased activation of the extrinsic pathway of the coagulation cascade due to excessive tissue factor production by macrophages and monocytes.[22]

After infection, a secreted glycoprotein, small soluble glycoprotein (sGP or GP) is synthesised. EBOV replication overwhelms protein synthesis of infected cells and the host immune defences. The GP forms a trimeric complex, which tethers the virus to the endothelial cells. The sGP forms a dimeric protein that interferes with the signalling of neutrophils, another type of white blood cell. This enables the virus to evade the immune system by inhibiting early steps of neutrophil activation.[medical citation needed]

Immune system evasion
Filoviral infection also interferes with proper functioning of the innate immune system.[48][50] EBOV proteins blunt the human immune system's response to viral infections by interfering with the cells' ability to produce and respond to interferon proteins such as interferon-alpha, interferon-beta, and interferon gamma.[49][93]

The VP24 and VP35 structural proteins of EBOV play a key role in this interference. When a cell is infected with EBOV, receptors located in the cell's cytosol (such as RIG-I and MDA5) or outside of the cytosol (such as Toll-like receptor 3 (TLR3), TLR7, TLR8 and TLR9) recognise infectious molecules associated with the virus.[49] On TLR activation, proteins including interferon regulatory factor 3 and interferon regulatory factor 7 trigger a signalling cascade that leads to the expression of type 1 interferons.[49] The type 1 interferons are then released and bind to the IFNAR1 and IFNAR2 receptors expressed on the surface of a neighbouring cell.[49] Once interferon has bound to its receptors on the neighbouring cell, the signalling proteins STAT1 and STAT2 are activated and move to the cell's nucleus.[49] This triggers the expression of interferon-stimulated genes, which code for proteins with antiviral properties.[49] EBOV's V24 protein blocks the production of these antiviral proteins by preventing the STAT1 signalling protein in the neighbouring cell from entering the nucleus.[49] The VP35 protein directly inhibits the production of interferon-beta.[93] By inhibiting these immune responses, EBOV may quickly spread throughout the body.[47]

Diagnosis
When EVD is suspected, travel, work history, and exposure to wildlife are important factors with respect to further diagnostic efforts.[medical citation needed]

Laboratory testing
Possible non-specific laboratory indicators of EVD include a low platelet count; an initially decreased white blood cell count followed by an increased white blood cell count; elevated levels of the liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST); and abnormalities in blood clotting often consistent with disseminated intravascular coagulation (DIC) such as a prolonged prothrombin time, partial thromboplastin time, and bleeding time.[94] Filovirions such as EBOV may be identified by their unique filamentous shapes in cell cultures examined with electron microscopy.[95]

The specific diagnosis of EVD is confirmed by isolating the virus, detecting its RNA or proteins, or detecting antibodies against the virus in a person's blood.[96] Isolating the virus by cell culture, detecting the viral RNA by polymerase chain reaction (PCR)[6][22] and detecting proteins by enzyme-linked immunosorbent assay (ELISA) are methods best used in the early stages of the disease and also for detecting the virus in human remains.[6][96] Detecting antibodies against the virus is most reliable in the later stages of the disease and in those who recover.[96] IgM antibodies are detectable two days after symptom onset and IgG antibodies can be detected six to 18 days after symptom onset.[22] During an outbreak, isolation of the virus with cell culture methods is often not feasible. In field or mobile hospitals, the most common and sensitive diagnostic methods are real-time PCR and ELISA.[97] In 2014, with new mobile testing facilities deployed in parts of Liberia, test results were obtained 3–5 hours after sample submission.[98] In 2015, a rapid antigen test which gives results in 15 minutes was approved for use by WHO.[99] It is able to confirm Ebola in 92% of those affected and rule it out in 85% of those not affected.[99]

Differential diagnosis
Early symptoms of EVD may be similar to those of other diseases common in Africa, including malaria and dengue fever.[24] The symptoms are also similar to those of other viral haemorrhagic fevers such as Marburg virus disease, Crimean Congo haemorrhagic fever, and Lassa fever.[100][101]

The complete differential diagnosis is extensive and requires consideration of many other infectious diseases such as typhoid fever, shigellosis, rickettsial diseases, cholera, sepsis, borreliosis, EHEC enteritis, leptospirosis, scrub typhus, plague, Q fever, candidiasis, histoplasmosis, trypanosomiasis, visceral leishmaniasis, measles, and viral hepatitis among others.[102]

Non-infectious diseases that may result in symptoms similar to those of EVD include acute promyelocytic leukaemia, haemolytic uraemic syndrome, snake envenomation, clotting factor deficiencies/platelet disorders, thrombotic thrombocytopenic purpura, hereditary haemorrhagic telangiectasia, Kawasaki disease, and warfarin poisoning

Kimberley Walsh

Kimberley Walsh

Kimberley Jane Scott[2] (née Walsh; born 20 November 1981)[1] is an English singer, model, television presenter, actress and dancer. She rose to fame in late 2002 when she auditioned for the reality series Popstars: The Rivals on ITV. The series announced that Walsh had won a place as a member of the girl group Girls Aloud.[3] The group achieved large success, having twenty consecutive top ten singles (including four number ones) in the UK, six studio albums have all been certified platinum by the British Phonographic Industry (BPI), two of which went to number one in the UK, and accumulating a total of five BRIT Award nominations. In 2009, Girls Aloud won "Best Single" with their song "The Promise".

During the group's hiatus, Walsh embarked on acting and presenting. In July 2010, she became a presenter on the music talkshow, Suck My Pop and presented coverage for the BAFTA Awards. In 2011, she appeared in Horrid Henry: The Movie as Prissy Polly. Musically, Walsh has featured on Aggro Santos's "Like U Like". In 2012, Walsh made her West End theatre debut, playing Princess Fiona in the London production of Shrek the Musical. She also fronted the 2009 Autumn/Winter collection for the fashion chain New Look and, in January 2011, she was revealed as the new face of Puma AG. In 2012, Walsh took part in Strictly Come Dancing, where she finished as one of the runners-up.

Since 2011, after making her West End debut in Shrek, Walsh has returned to perform in stage versions popular films such as Elf in 2015, before Big and Sleepless in Seattle both in 2019.
Early life
Walsh was born in Bradford, West Yorkshire,[1][4] the daughter of John and Diane Walsh. She grew up with three siblings, Sally Walsh, Amy Walsh and Adam Walsh in Allerton, West Yorkshire.[1] Sally played the character of Lyn Hutchinson on the soap opera Emmerdale between 1997 and 2000,[1] and Amy joined the show's cast in 2014 as Tracy Shankley.[5]

Walsh attended Sandy Lane Primary School, Stoney Lee Middle School, and Beckfoot Grammar School,[6] and had her first taste of fame appearing in an advert as a child along with sister Sally in an Asda advert. She starred as Young Cosette in a regional production of Les Misérables and starred in ITV's The Book Tower in 1986.[citation needed] Walsh attended the Bradford theatre school, Stage 84, and briefly taught there.

Music career
Girls Aloud
Walsh auditioned for the reality television show Popstars The Rivals in 2002 with the song "Where Do Broken Hearts Go".[7] Several thousand applicants attended auditions across the UK in hope of being selected. Ten girls and ten boys were chosen as finalists by judges Pete Waterman, Louis Walsh and Geri Halliwell. Walsh did not initially make it into the group of ten female contestants who were to appear on the show. However, when another contestant was disqualified on a technicality, she found herself on the show. These finalists then took to the stage participating in weekly Saturday night live performances which alternated weekly between the girls and boys. Each week, the contestant polling the fewest phone votes was eliminated, until the final line-ups of the groups emerged. Walsh joined Nadine Coyle, Sarah Harding, Nicola Roberts, and Cheryl Tweedy to comprise the new girl group Girls Aloud, formed through the show by a public vote on 30 November 2002
The group's debut single "Sound of the Underground" peaked at number one on the UK Singles Chart, becoming the 2002 Christmas number one.[8] Girls Aloud hold the record for the shortest time between formation and reaching number one.[9] The group released their debut album Sound of the Underground in May 2003,[10] which entered the charts at number two and was certified platinum by the British Phonographic Industry (BPI) later the same year. Their singles "I'll Stand by You", "Walk This Way", and "The Promise" have charted at number one. Two of their albums have reached the top of the UK Albums Chart: their greatest hits album The Sound of Girls Aloud and 2008's Out of Control, both of which entered the chart at number one, with over one million copies of the former being sold.[11]

They also achieved seven certified albums and have been nominated for five Brit Awards, winning the 2009 Best Single for "The Promise".

The group's musical style is pop, but throughout their career they had experimented with electropop and dance-pop. Girls Aloud's collaborations with Brian Higgins and his songwriting and production team Xenomania earned the group critical acclaim,[12] due to an innovative approach to mainstream pop music. The group became one of the few UK reality television acts to achieve continued success, amassing a fortune of £30 million by May 2010. Guinness World Records lists them as "Most Successful Reality TV Group" in the 2007 edition. They also hold the record for "Most Consecutive Top Ten Entries in the UK by a Female Group" in the 2008 edition, and are credited again for "Most Successful Reality TV Group" in the 2011 edition. The group was also named the United Kingdom's biggest selling girl group of the 21st century, with over 4.3 million singles sales and 4 million albums sold in the UK alone.[13][14]

In July 2009, Girls Aloud announced they would take a year-long hiatus to pursue solo projects.[15] In August 2010, bandmate Nicola Roberts revealed that she was not anticipating a reunion of Girls Aloud until 2012.[16] Walsh had revealed that she does not think it is possible Girls Aloud will ever "officially break up". She explained that they are planning to tour again and will probably take breaks from time to time, doing solo projects but they will never permanently go their separate ways.[17]

After Girls Aloud's three years of hiatus, the group reunited for their 10th anniversary. The group released their new single, "Something New" on 18 November 2012. The music video for the song was filmed in October 2012, and premiered on YouTube on 19 October 2012.[18] The song was also the official charity single for Children in Need in 2012. The group released their second greatest hits compilation, Ten on 26 November 2012. In 2013, the group embarked on Ten - The Hits Tour 2013. They announced their split soon after the tour ended.[19][20]

Solo work
It was first rumoured that Walsh was about to make a record deal with her band's record label, Fascination Records,[21] although nothing has been confirmed. Soon after the rumour, Walsh confirmed on Suck My Pop, a programme that she co-hosts on the television channel Viva in the United Kingdom, that she will feature on English rapper Aggro Santos' upcoming single, "Like U Like". The track will be her first step away from Girls Aloud as a singer. Walsh was asked for OK! Magazine: "Kimberley, there are rumours, that you will be releasing a solo album..." and Walsh said: "Gosh! I haven't got any plan to do that. Gary Barlow signed Aggro Santos and he asked me to sing Like U Like, and I've done a song for the Horrid Henry film that I'm in titled "Everybody Dance". I'm not sure about doing anything big on my own just yet." In 2012 she made her West End theatre debut, playing Princess Fiona in the London production of Shrek the Musical. The announcement came after Amanda Holden announced her pregnancy in August 2011.[22] Walsh teamed up with Alfie Boe to record a version of Queen's "One Vision" as the Official Olympic Team Great Britain Single. Walsh has also performed with several artists including Neyo with "Hate That I Love You", Ronan Keating's "No Matter What" and James Cullum with "Rainy Days and Mondays". In August 2012 it was announced that Walsh is in discussions with Gary Barlow to release a solo album for a 2013 release.

On 7 September 2012, Walsh was announced as one of the 14 celebrities, competing in tenth series of Strictly Come Dancing.[23] Her professional partner is last year's runner-up Pasha Kovalev.[24] She received 3 perfect 40s during the series, and she finished as one of the runners-up alongside presenter Denise Van Outen, behind the winner Olympian Louis Smith.

On 4 February 2013 Walsh released, through Decca Records, her debut album Centre Stage which features a series of popular musical tunes as well as two brand new tracks.[25]

Walsh has written her own autobiography, called A Whole Lot of History. The book was released on 26 September 2013.

In March 2014, Walsh took part in recording England's 2014 World Cup song. She collaborated with the likes of fellow pop stars Melanie C, Eliza Doolittle, Emma Bunton, Conor Maynard, Katy B and Pixie Lott, on "Greatest Day", a track originally performed by British band, Take That. The track was produced by Gary Barlow and recorded at Sarm Studios in London. The track also featured past footballers such as Gary Lineker, Michael Owen, Geoff Hurst, David Seaman, Peter Shilton, Glenn Hoddle and Dion Dublin on backing vocals.[26]

Television
Acting
Before Walsh became a member of Girls Aloud, she had worked in theatre and acting.[27] In 2000 Walsh appeared in the television series This Is Personal: The Hunt for the Yorkshire Ripper as Gillian Oldfield, and starred in a BBC Educational Schools programme called Focus. In the same year, Walsh applied for the role of Maria Sutherland in Coronation Street. However, she lost out to Samia Ghadie.[28] In 2001, Walsh played Tracy in Dream Back. In 2007, alongside her bandmates she appeared in St. Trinian's playing a school band member. In 2008 she and bandmate Nicola Roberts had small parts in Britannia High, in which they played themselves. Walsh has recently stated that she would like to star in a musical in the future, playing a stage role.[29] In late 2010, Walsh landed a role in the live-action 3D family comedy film Horrid Henry: The Movie as the titular character's overactive cousin Prissy Polly, with the film being released on 29 July 2011. Walsh also appeared in the 2013 movie All Stars, alongside Theo Stevenson once again, who she appeared with first in Horrid Henry: The Movie. She plays the minor role of his character's mother.

On 5 October 2011 through 21 May 2012 she made her West End theatre debut, playing Princess Fiona in the London production of Shrek the Musical. The announcement came after Amanda Holden announced her pregnancy in August 2011.[22] Originally signed on until 27 February 2012, she extended her run to 21 May 2012. She subsequently returned to the West End stage in October 2015, playing the role of Jovie in Elf: The Musical.[30]

In 2018 she was cast in series two of Ackley Bridge as the character, Claire Butterworth.

In autumn 2019, Walsh returned to the west end in the cast of BIG the Musical.

Presenting
Walsh appeared in Let's Dance for Sport Relief as a panellist and also fronted coverage of the BAFTA Awards for MTV on her own programme Kimberley Walsh at the BAFTAS in 2010 and in the summer of 2010 hosted sky 1 documentary "Girl in the Blue Jeans". She also presented coverage for The X Factor live from South Shields on the day of the final in 2009 for Joe McElderry. On 17 – 18 June 2010, Walsh hosted Channel 4's The 5 O'Clock Show with Stephen Mulhern. Walsh appeared in her own documentary for Sky 1 named Kimberley Walsh: Blue Jean Girl which aired on Wednesday, 17 June 2010. On the same day, Walsh appeared on This Morning to promote the show. Walsh later became a presenter of new music talk-show, titled Suck My Pop, on Viva. Walsh also starred as a judge for ITV's entertainment show Born To Shine.

On the 9 April 2016, Walsh co-presented Weekend Brunch the Grand National Day special with Tim Lovejoy.

Other ventures
Walsh climbed Mount Kilimanjaro in aid of Comic Relief in March 2009. The climb, organised by Gary Barlow, was also undertaken by fellow Girls Aloud member Cheryl, Alesha Dixon, Fearne Cotton, Denise Van Outen, Chris Moyles, Ben Shephard, Ronan Keating and Barlow himself. Between 3 February and 23 March 2009, Walsh, Cole, Barlow, Moyles and Cotton also raised money for Comic Relief by providing the voice for the BT Speaking Clock.[citation needed]

As of 26 August 2009, Walsh was modelling for the clothing line New Look following in the footsteps of Lily Allen and Alexa Chung.[citation needed] Walsh became OK! magazine's new weekly columnist in August 2010. The column is called "Kimberley Calls The Shots".[31]

She was also named as the new face and hair of Schwarzkopf for a reported 6 figure deal.[32] In March 2011, Walsh teamed up with Tess Daly and Joanna Page to work with Maltesers to promote Red Nose Day 2011.[33] In January 2011, Walsh was revealed as the new face of Puma AG BodyTrain fitness toner wear.[34] In May 2011, Walsh was named as the face of Right Guard's Xtreme Dry Range.[35]

In 2017, Kimberley launched a children’s clothing line called “Kimba’s Kids” which she runs with her brother. In September 2019, she signed with outdoor clothing company Regatta.

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