الجمعة، 24 يوليو 2020

Thyroid cancer

Thyroid cancer

Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and have the potential to spread to other parts of the body.  Symptoms can include swelling or a lump in the neck.  Cancer can also occur in the thyroid after spread from other locations, in which case it is not classified as thyroid cancer. 

Risk factors include radiation exposure at a young age, having an enlarged thyroid, and family history.  The four main types are papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, and anaplastic thyroid cancer.  Diagnosis is often based on ultrasound and fine needle aspiration.  Screening people without symptoms and at normal risk for the disease is not recommended as of 2017. 

Treatment options may include surgery, radiation therapy including radioactive iodine, chemotherapy, thyroid hormone, targeted therapy, and watchful waiting.  Surgery may involve removing part or all of the thyroid.  Five-year survival rates are 98% in the United States. 

Globally as of 2015, 3.2 million people have thyroid cancer.  In 2012, 298,000 new cases occurred.  It most commonly occurs between the ages of 35 and 65.  Women are affected more often than men.  Those of Asian descent are more commonly affected.  Rates have increased in the last few decades, which is believed to be due to better detection.  In 2015, it resulted in 31,900 deaths. 
Most often, the first symptom of thyroid cancer is a nodule in the thyroid region of the neck.  However, up to 65% of adults have small nodules in their thyroids, but typically under 10% of these nodules are found to be cancerous.  Sometimes, the first sign is an enlarged lymph node. Later symptoms that can be present are pain in the anterior region of the neck and changes in voice due to an involvement of the recurrent laryngeal nerve.

Thyroid cancer is usually found in a euthyroid patient, but symptoms of hyperthyroidism or hypothyroidism may be associated with a large or metastatic, well-differentiated tumor.

Thyroid nodules are of particular concern when they are found in those under the age of 20. The presentation of benign nodules at this age is less likely, thus the potential for malignancy is far greater.
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Azim Premji

Azim Premji

Azim Hashim Premji (born 24 July 1945) is an Indian business tycoon, investor, engineer, and philanthropist, who is the chairman of Wipro Limited. He is informally known as the Czar of the Indian IT Industry.  He was responsible for guiding Wipro through four decades of diversification and growth, to finally emerge as one of the global leaders in the software industry.  In 2010, he was voted among the 20 most powerful men in the world by Asiaweek.  He has twice been listed among the 100 most influential people by TIME Magazine, once in 2004 and more recently in 2011.  For years, he has been regularly listed one among the 500 Most Influential Muslims of the world. 
He was named the nineteenth richest person in India with an estimated net worth of US$6.5 billion according to the India's Richest 2019 list by Forbes.  In 2013, he agreed to give away at least half of his wealth by signing The Giving Pledge. Premji started with a $2.2 billion donation to the Azim Premji Foundation, focused on education in India. 
Premji was born in Bombay, India in a Muslim family.  His father was a noted businessman and was known as Rice King of Burma. Muhammad Ali Jinnah, founder of Pakistan, invited his father Muhammed Hashem Premji to come to Pakistan, he turned down the request and chose to remain in India. 

Premji has a Bachelor of Science in Electrical Engineering degree from Stanford University.  He is married to Yasmeen. The couple have two children, Rishad and Tariq. Rishad is currently the Chief Strategy Officer of IT Business, Wipro. 
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Leon Balogun

Leon Balogun

Leon Aderemi Balogun (born 28 June 1988) is a Nigerian professional footballer who plays as a defender for Scottish Premiership side Rangers and the Nigerian national football team.
He made his Bundesliga debut on 19 April 2009 for Hannover 96 in a game against Hamburger SV. 

After his contract with 2. Bundesliga side Fortuna Düsseldorf had been expired in summer 2014, he was without a club for three months until he joined fellow leaguer Darmstadt 98. He signed a contract until the end of the 2014–15 season. 
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Miriam Margolyes

Miriam Margolyes

Miriam Margolyes, OBE (/ˈmɑːrɡəliːz/; born 18 May 1941) is a British-Australian actress. Her earliest roles were in theatre; after several supporting roles in film and television, she won a BAFTA Award for her role in Martin Scorsese's The Age of Innocence (1993) and was cast in the role of Professor Sprout in the Harry Potter film series.

Margolyes has spent many years dividing her time between England, Australia, and Italy. She has starred in productions in both England and Australia, including the Australian premiere of the 2013 play I'll Eat You Last. She became an Australian citizen in 2013.
Margolyes was born in Oxford on 18 May 1941,  the only child of Ruth (née Walters; 1905–1974), an English property investor and developer, and Joseph Margolyes (1899–1995), a Scottish physician from the Gorbals area of Glasgow.  She grew up in a Jewish family,  with ancestors who moved to the UK from Belarus and Poland. Her great-grandfather, Symeon Sandmann, was born in the Polish town of Margonin, which Margolyes visited in 2013. She attended Oxford High School and Newnham College, Cambridge, where she read English.  There, in her 20s, she began acting and appeared in productions by the Cambridge Footlights.  She represented Newnham College in the first series of University Challenge, where she may have been one of the first people to say "fuck" on British television; she claims to have used the word in frustration on the show in 1963
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The Shining

The Shining

The Shining is a 1980 psychological horror film produced and directed by Stanley Kubrick and co-written with novelist Diane Johnson. The film is based on Stephen King's 1977 novel of the same name and stars Jack Nicholson, Shelley Duvall, Scatman Crothers, and Danny Lloyd.

The film's central character is Jack Torrance (Nicholson), an aspiring writer and recovering alcoholic who accepts a position as the off-season caretaker of the isolated historic Overlook Hotel in the Colorado Rockies. Wintering over with Jack are his wife, Wendy Torrance (Duvall) and young son, Danny Torrance (Lloyd). Danny possesses "the shining", psychic abilities that enable him to see into the hotel's horrific past. The hotel cook, Dick Hallorann (Crothers), also has this ability and is able to communicate with Danny telepathically. The hotel had a previous winter caretaker who went insane and killed his family and himself. After a winter storm leaves the Torrances snowbound, Jack's sanity deteriorates due to the influence of the supernatural forces that inhabit the hotel, placing his wife and son in danger.

Production took place almost exclusively at EMI Elstree Studios, with sets based on real locations. Kubrick often worked with a small crew, which allowed him to do many takes, sometimes to the exhaustion of the actors and staff. The new Steadicam mount was used to shoot several scenes, giving the film an innovative and immersive look and feel. There has been much speculation into the meanings and actions in the film because of inconsistencies, ambiguities, symbolism, and differences from the book.

The film was released in the United States on May 23, 1980, and in the United Kingdom on October 2, 1980, by Warner Bros. There were several versions for theatrical releases, each of which was cut shorter than the one preceding it; about 27 minutes were cut in total. Reactions to the film at the time of its release were mixed; Stephen King criticized the film due to its deviations from the novel. Critical opinion has become more favorable and it has become a staple of pop culture. In 2018, the film was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically, or aesthetically significant".  A sequel, Doctor Sleep, was released on November 8, 2019, in the United States, and on October 31, 2019, in Europe.
Writer Jack Torrance arrives at the remote Overlook Hotel in the Rocky Mountains to be interviewed for the position of winter caretaker. The hotel, which opened in 1909 and was built on the site of a Native American burial ground, closes during the snowed-in months. Once hired, Jack plans to use the hotel's solitude to write. Manager Stuart Ullman warns Jack about the hotel's reputation: a previous caretaker, Delbert Grady, killed his family and himself. Jack is nevertheless impressed with the hotel and gets the job. In Boulder, Jack's son, Danny, has a premonition about the hotel, and Jack's wife, Wendy, tells a doctor about Danny's imaginary friend, Tony. She also reveals that Jack is a recovering alcoholic who once injured Danny in a drunken rage.

When the family moves into the hotel, head chef Dick Hallorann surprises Danny by telepathically offering him ice cream. Hallorann explains to Danny that he and his grandmother shared this telepathic ability, which he calls "shining". Hallorann tells Danny that the hotel has a "shine" and its own memories. He also tells Danny to stay away from room 237.

A month passes; while Jack's writing goes nowhere, Danny and Wendy explore the hotel's hedge maze and Hallorann goes to Florida. Wendy learns that the phone lines are out due to the heavy snowfall. Danny has frightening visions, while Jack becomes prone to violent outbursts as his mental health deteriorates. Danny's curiosity about room 237 overcomes him when he sees the room's door open. Later, Wendy finds Jack screaming during a nightmare while asleep at his typewriter. After she awakens him, Jack says he dreamed that he killed her and Danny. Danny arrives, visibly traumatized and bruised. Wendy accuses Jack of abusing him, which Jack denies.

Jack wanders into the hotel's Gold Room and meets a ghostly bartender named Lloyd, to whom he complains about his marriage. Wendy tells Jack that Danny told her a "crazy woman" in room 237 attempted to strangle him. Jack investigates room 237 and encounters a dead woman's ghost, but he tells Wendy that he saw nothing. Wendy and Jack argue over whether Danny should be removed from the hotel, and Jack returns to the Gold Room, which is now filled with ghosts attending a ball. He meets a ghostly waiter who identifies himself as Delbert Grady. The ghost informs Jack that Danny has reached out to Hallorann using his "talent", and says that Jack must "correct" his wife and child. After telepathically sensing Danny's fear, Halloran flies back to Colorado. Danny calls out "redrum" and goes into another trance, referring to himself as "Tony".

Wendy discovers that Jack has been typing pages filled with the phrase "All work and no play makes Jack a dull boy". She begs a psychotic Jack to leave the hotel with Danny, but he threatens her. Wendy knocks him unconscious with a baseball bat and locks him in the kitchen pantry, but she and Danny are both trapped as Jack has disabled the hotel's two-way radio and snowcat. Jack converses through the pantry door with Grady, who unlocks the door, freeing Jack.

Danny continues chanting and drawing the word "REDRUM". When Wendy sees the word reversed in the bedroom mirror, the word is revealed to be "MURDER". Jack hacks through the quarters' main door with an axe. Wendy sends Danny through the bathroom window, but cannot get out herself. Jack breaks through the door, but retreats after Wendy slashes his hand with a knife. Hearing Hallorann arriving in a snowcat, Jack ambushes and murders him in the lobby, then pursues Danny into the hedge maze. Wendy runs through the hotel looking for Danny, encountering ghosts, a cascade of blood Danny envisioned in Boulder, and Hallorann's corpse. Danny lays a false trail to mislead Jack and hides behind a snowdrift.

Danny escapes from the maze and reunites with Wendy; they leave in Hallorann's snowcat, while Jack freezes to death after losing Danny's trail. In a photograph in the hotel hallway, Jack is pictured standing amid a crowd of party revelers from 1921.
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Stacey Solomon

Stacey Solomon

Stacey Chanelle Clare Solomon (born 4 October 1989) is an English singer and television personality. In 2009, she finished in third place on the sixth series of The X Factor, and gained a number one single on the UK Singles Chart when her fellow The X Factor finalists released a cover of "You Are Not Alone".

Solomon won the tenth series of I'm a Celebrity... Get Me Out of Here!.  Her debut single, a cover of "Driving Home for Christmas", was released on 19 December 2011.  Solomon then released her debut album Shy on 18 April 2015. In September 2016, she began appearing as a panellist on Loose Women and in November of the same year, she presented I'm a Celebrity: Extra Camp.
Solomon was born in Dagenham. Her father is from a Jewish family that had emigrated to Britain from Iraq and Poland. Her mother was born into a Church of England family (the daughter of a vicar), and had converted to Judaism before marrying Stacey's father.  Her parents divorced when she was nine.  She attended King Solomon High School.
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Rahkeem Cornwall

Rahkeem Cornwall

Rahkeem Rashawn Shane Cornwall (born 1 February 1993) is an Antiguan cricketer. A right-arm off-break bowler, Cornwall has played for Leeward Islands cricket team and featured in the line-up for the Antigua Hawksbills in the Caribbean Premier League. He is the heaviest cricketer to play international cricket.  In August 2019, Cricket West Indies named him as the Championship Player of the Year.  Later the same month, he made his international debut for the West Indies cricket team. He also set the record for the heaviest cricketer to play in Test cricket, weighing more than 140kg (22 stone).

Career
In July 2016, he was selected for the West Indies Cricket Board President's XI to face the touring Indian Team; he top-scored in his team's first innings with 41, before taking 5 wickets in India's innings. For the same team in 2017, he faced the touring England team; he scored an important 59 runs in a partnership of 123, helping his team recover from 55–5 to 233. He then took 1 wicket in an economical bowling spell in the narrow loss.  He once again played for the Cricket Board President's XI against Pakistan in a warm-up game during their 2017 tour.  In October 2016, he was selected for the West Indies A tour of Sri Lanka, taking part in all 3 matches unofficial Test matches; while disappointing with the bat, he went on to take a series-high 23 wickets at an average of below 20.  In a Regional Four Day Competition game versus Guyana in April 2017, he captained the Leeward Islands in the absence of Kieran Powell, who had been recalled to the West Indies Test side.  He finished the competition as the joint third-highest wicket-taker, with the most for his team.  Cornwall is also known to have spent several months playing in England, during this time he played for Thames Ditton CC and was used as a lethal bowler and occasionally damaging batsman. Cornwall became celebrated in the club for drinking a yard of beer faster than anyone else.

In 2017, he was selected by the St Lucia Stars in the CPL Draft for the upcoming season.  In a disappointing season for the team, Cornwall was one of the more promising members of the squad; he finished the tournament with the second-best batting average in the side, as well being one of its more economical bowlers.  His best performance came in a loss to the Barbados Tridents; having been promoted up the order to open, Cornwall reached his 50 off 26 balls (his first in T20 cricket), giving the Stars hope of chasing their target of 196. However, he retired hurt on 78 after being hit in the stomach by a bouncer from Kieron Pollard with 47 runs needed from 3 overs. This decision was not well-received by Pollard , and St Lucia went on to lose the match.

He was the leading wicket-taker for the Leeward Islands in the 2018–19 Regional Super50 tournament, with fourteen dismissals in eight matches.  He was then the top wicket-taker in the 2018–19 Regional Four Day competition, taking 54 wickets, despite only playing 9 matches;  these performances helped his team to 3rd place in the table. However, a controversial declaration by Cornwall, who was stand-in captain for the last game of the season, in an attempt to stop their opponents, Barbados, from finishing 2nd, backfired spectacularly. 

In August 2019, he was named in the West Indies' Test squad for their series against India.  He made his Test debut for the West Indies, against India, on 30 August 2019.  At 140 kg (308 lbs/22 st), he is the heaviest man to play Test cricket, though no accurate record exists of the weight of W.G.Grace in 1899, the year of his retirement. 
In October 2019, he was named in the Leeward Islands' squad for the 2019–20 Regional Super50 tournament.  The following month, in the one-off Test match against Afghanistan, Cornwall took his first five-wicket haul in Test cricket 

In June 2020, Cornwall was named in the West Indies' Test squad, for their series against England.  The Test series was originally scheduled to start in May 2020, but was moved back to July 2020 due to the COVID-19 pandemic. 

In July 2020, he was named in the St Lucia Zouks squad for the 2020 Caribbean Premier League. 

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